EFFECT OF SUB MINIMUM INHIBITORY CONCENTRATION OF DI-ALLYL-DI-SULPHIDE (DADS) ON GROWTH CURVE AND TIME KILL CURVE IN STAPHYLOCOCCUS AUREUS ATCC STRAI

1
Dr. Farheen Fatima
Dr. Farheen Fatima
2
Dr. KASHINATH R T
Dr. KASHINATH R T

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EFFECT OF SUB MINIMUM INHIBITORY CONCENTRATION OF DI-ALLYL-DI-SULPHIDE (DADS) ON GROWTH CURVE AND TIME KILL CURVE IN STAPHYLOCOCCUS AUREUS ATCC STRAI Banner

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The objective of our study was to evaluate, in a population of Togolese People Living With HIV(PLWHIV), the agreement between three scores derived from the general population namely the Framingham score, the Systematic Coronary Risk Evaluation (SCORE), the evaluation of the cardiovascular risk (CVR) according to the World Health Organization.
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Studies have shown that garlic and its extracts possess antibacterial, antifungal and antiviral activities. DADS, which is an principle compound of garlic oil is an established hypolipidemic substance and hence may alter the cellular as well as membrane lipid composition and content in microbes thus probably show the antimicrobial activity. DADS is effective against Staphylococcus aureus and its Minimum inhibitory concentration (MIC=1mg/L) and Minimum Bactericidal Concentration (MBC=2mg/L) have been established. In the present work we have studied the effect of sub-MIC (0.125mg/L) level of DADS on growth curve and time kill curve in Staphylococcus aureus in order to establish its mode of action. The experiments show a significant inhibition of S. aureus as well as a time related decrease in viable count indicating DADS at sub MIC levels may be useful in treatment of S. aureus infections.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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Farheen Fatima. 1970. \u201cEFFECT OF SUB MINIMUM INHIBITORY CONCENTRATION OF DI-ALLYL-DI-SULPHIDE (DADS) ON GROWTH CURVE AND TIME KILL CURVE IN STAPHYLOCOCCUS AUREUS ATCC STRAI\u201d. Unknown Journal GJMR Volume 10 (GJMR Volume 10 Issue 3): .

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September 10, 2010

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Studies have shown that garlic and its extracts possess antibacterial, antifungal and antiviral activities. DADS, which is an principle compound of garlic oil is an established hypolipidemic substance and hence may alter the cellular as well as membrane lipid composition and content in microbes thus probably show the antimicrobial activity. DADS is effective against Staphylococcus aureus and its Minimum inhibitory concentration (MIC=1mg/L) and Minimum Bactericidal Concentration (MBC=2mg/L) have been established. In the present work we have studied the effect of sub-MIC (0.125mg/L) level of DADS on growth curve and time kill curve in Staphylococcus aureus in order to establish its mode of action. The experiments show a significant inhibition of S. aureus as well as a time related decrease in viable count indicating DADS at sub MIC levels may be useful in treatment of S. aureus infections.

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EFFECT OF SUB MINIMUM INHIBITORY CONCENTRATION OF DI-ALLYL-DI-SULPHIDE (DADS) ON GROWTH CURVE AND TIME KILL CURVE IN STAPHYLOCOCCUS AUREUS ATCC STRAI

Dr. Farheen Fatima
Dr. Farheen Fatima
Dr. KASHINATH R T
Dr. KASHINATH R T

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