EFFECT OF SUB MINIMUM INHIBITORY CONCENTRATION OF DI-ALLYL-DI-SULPHIDE (DADS) ON GROWTH CURVE AND TIME KILL CURVE IN STAPHYLOCOCCUS AUREUS ATCC STRAI

§ Basaveshwara Medical College & Hospital

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EFFECT OF SUB MINIMUM INHIBITORY CONCENTRATION OF DI-ALLYL-DI-SULPHIDE (DADS) ON GROWTH CURVE AND TIME KILL CURVE IN STAPHYLOCOCCUS AUREUS ATCC STRAI

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EFFECT OF SUB MINIMUM INHIBITORY CONCENTRATION OF DI-ALLYL-DI-SULPHIDE (DADS) ON GROWTH CURVE AND TIME KILL CURVE IN STAPHYLOCOCCUS AUREUS ATCC STRAI Banner

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Abstract

Studies have shown that garlic and its extracts possess antibacterial, antifungal and antiviral activities. DADS, which is an principle compound of garlic oil is an established hypolipidemic substance and hence may alter the cellular as well as membrane lipid composition and content in microbes thus probably show the antimicrobial activity. DADS is effective against Staphylococcus aureus and its Minimum inhibitory concentration (MIC=1mg/L) and Minimum Bactericidal Concentration (MBC=2mg/L) have been established. In the present work we have studied the effect of sub-MIC (0.125mg/L) level of DADS on growth curve and time kill curve in Staphylococcus aureus in order to establish its mode of action. The experiments show a significant inhibition of S. aureus as well as a time related decrease in viable count indicating DADS at sub MIC levels may be useful in treatment of S. aureus infections.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr. Fatima. . "EFFECT OF SUB MINIMUM INHIBITORY CONCENTRATION OF DI-ALLYL-DI-SULPHIDE (DADS) ON GROWTH CURVE AND TIME KILL CURVE IN STAPHYLOCOCCUS AUREUS ATCC STRAI". Global Journal of Medical Research GJMR Volume 10 (GJMR Volume 10 Issue 3).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
Classification
GJMR-K NLMC Classification QW 52
QW 142.5.C6
Version of record

v1.2

Issue date
September 10, 2010

Language
English
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EFFECT OF SUB MINIMUM INHIBITORY CONCENTRATION OF DI-ALLYL-DI-SULPHIDE (DADS) ON GROWTH CURVE AND TIME KILL CURVE IN STAPHYLOCOCCUS AUREUS ATCC STRAI

Dr. Fatima
Dr. Fatima Basaveshwara Medical College & Hospital