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Studies have shown that garlic and its extracts possess antibacterial, antifungal and antiviral activities. DADS, which is an principle compound of garlic oil is an established hypolipidemic substance and hence may alter the cellular as well as membrane lipid composition and content in microbes thus probably show the antimicrobial activity. DADS is effective against Staphylococcus aureus and its Minimum inhibitory concentration (MIC=1mg/L) and Minimum Bactericidal Concentration (MBC=2mg/L) have been established. In the present work we have studied the effect of sub-MIC (0.125mg/L) level of DADS on growth curve and time kill curve in Staphylococcus aureus in order to establish its mode of action. The experiments show a significant inhibition of S. aureus as well as a time related decrease in viable count indicating DADS at sub MIC levels may be useful in treatment of S. aureus infections.
Dr. Fatima. . "EFFECT OF SUB MINIMUM INHIBITORY CONCENTRATION OF DI-ALLYL-DI-SULPHIDE (DADS) ON GROWTH CURVE AND TIME KILL CURVE IN STAPHYLOCOCCUS AUREUS ATCC STRAI". Global Journal of Medical Research GJMR Volume 10 (GJMR Volume 10 Issue 3).
Crossref Journal DOI 10.17406/gjmr
Print ISSN 0975-5888
e-ISSN 2249-4618
v1.2
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Total Score: 152
Country: India
Subject: Global Journal of Medical Research
Authors: Dr. Farheen Fatima, Dr. KASHINATH R T (PhD/Dr. count: 2)
View Count (all-time): 269
Total Views (Real + Logic): 5693
Total Downloads (simulated): 110
Publish Date: 2010 05, Sat
Monthly Totals (Real + Logic):
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