Effect of Trichopus Zeylanicus Leaf Extract on Acute Stress Induced Anxiety in Mice

1
D. Yashwanth Kumar
D. Yashwanth Kumar
2
Raghu Ram. A
Raghu Ram. A
3
S.N. Sri Harsha
S.N. Sri Harsha
4
K.S.S.N. Neelima
K.S.S.N. Neelima
1 PACIFIC University,

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Trichopus zeylanicus Gaertn. (Dioscoreaceae) [TZ] leaf is traditionally used as a general health tonic in tribal regions of south India. In the present study the effect of alcoholic extract of TZ leaves was evaluated on acute stress induced anxiety in mice at oral doses of 100mg/kg, 250mg/kg and 500mg/kg. Acute stress was induced by restraint stress method and the stressed rodents were evaluated in light and dark model and elevated plus maze. The extract at the doses of 250mg/kg and 500mg/kg showed a significant increase in the number of crossings and reduced time spent in the dark chamber in light and dark model. Further, it significantly reduced the time spent in the closed arm in elevated plus maze as compared to stressed mice. Moreover, TZ significantly reduced stress induced increased plasma corticosterone levels and hyperglycemia in rats.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

D. Yashwanth Kumar. 2014. \u201cEffect of Trichopus Zeylanicus Leaf Extract on Acute Stress Induced Anxiety in Mice\u201d. Global Journal of Medical Research - G: Veterinary Science & Medicine GJMR-G Volume 13 (GJMR Volume 13 Issue G2): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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v1.2

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January 29, 2014

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English

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Trichopus zeylanicus Gaertn. (Dioscoreaceae) [TZ] leaf is traditionally used as a general health tonic in tribal regions of south India. In the present study the effect of alcoholic extract of TZ leaves was evaluated on acute stress induced anxiety in mice at oral doses of 100mg/kg, 250mg/kg and 500mg/kg. Acute stress was induced by restraint stress method and the stressed rodents were evaluated in light and dark model and elevated plus maze. The extract at the doses of 250mg/kg and 500mg/kg showed a significant increase in the number of crossings and reduced time spent in the dark chamber in light and dark model. Further, it significantly reduced the time spent in the closed arm in elevated plus maze as compared to stressed mice. Moreover, TZ significantly reduced stress induced increased plasma corticosterone levels and hyperglycemia in rats.

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Effect of Trichopus Zeylanicus Leaf Extract on Acute Stress Induced Anxiety in Mice

Raghu Ram. A
Raghu Ram. A
S.N. Sri Harsha
S.N. Sri Harsha
D. Yashwanth Kumar
D. Yashwanth Kumar PACIFIC University,
K.S.S.N. Neelima
K.S.S.N. Neelima

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