Effects of Exercise on Doxorubicin Accumulation and Multidrug Resistance Protein Expression in Striated Muscle

David Hydock; Colin J Quinn; Noah M. Gibson

Effects of Exercise on Doxorubicin Accumulation and Multidrug Resistance Protein Expression in Striated Muscle

David Hydock * §

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Colin J Quinn

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Noah M. Gibson

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kpfannenstiel

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abashore

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University of Northern Colorado

Effects of Exercise on Doxorubicin Accumulation and Multidrug Resistance Protein Expression in Striated Muscle

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Abstract

The chemotherapy drug doxorubicin (DOX) is well known to induce cardiac and skeletal muscle dysfunction. Previous studies demonstrate that exercise can mitigate dysfunction, reduce myocardial DOX accumulation, and depress markers of oxidative stress, but a putative mechanism is unknown. The aim of this study was to determine whether multidrug resistance protein (MRP) expression contributes to the protective effects of exercise against DOX-induced muscular dysfunction. Lower left ventricle (LV) and soleus DOX concentrations were observed in exercised animals, and MRP-1, MRP-2, and MRP-7 expression was significantly increased in the LV with exercise. No MRP variations were apparent in skeletal muscles following the exercise protocol. As a marker of oxidative stress, malondialdehyde+4 hydroxyalkenal levels were analyzed, and exercise reduced both cardiac and skeletal muscle levels from exercised trained animals treated with DOX had significantly lower levels than SED-DOX. This study suggests increased MRP expression with exercise may contribute to exercise-induced protection in cardiac muscle but not skeletal muscle.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

David Hydock, Colin J Quinn, Noah M. Gibson, kpfannenstiel, abashore. 2017. "Effects of Exercise on Doxorubicin Accumulation and Multidrug Resistance Protein Expression in Striated Muscle". Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 16 (GJMR Volume 16 Issue K6).

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GJMR Volume 16 Issue K6

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR Classification NLMC Code: WE 500

Submission ReceivedDecember 12, 2015
Peer Review Double Blind
Handling Editor
Accepted January 4, 2016
Published January 15, 2016

Version of record

v1.2

Issue date

February 4, 2017

Language

English

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Article Matrices

Total Score: 176

Country: United States

Subject: Global Journal of Medical Research

Authors: Colin J Quinn, Noah M. Gibson, Keith B. Pfannenstiel, Alex C. Bashore, Reid Hayward, David S. Hydock (PhD/Dr. count: 0)

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Publish Date: 2016 01, Fri

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