Efficacy and Safety of Vitamin D3 (Cholecalciferol) Oral Solution Compared to Tablet and Capsule: A Randomized, Parallel-Design, Active-Controlled Study

1
Krishnakumar M Nandgaye
Krishnakumar M Nandgaye
2
Santoshi B. Kadam
Santoshi B. Kadam
3
Dr. Prashant J. Palkar
Dr. Prashant J. Palkar

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Efficacy and Safety of Vitamin D3 (Cholecalciferol) Oral Solution Compared to Tablet and Capsule: A Randomized, Parallel-Design, Active-Controlled Study Banner
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We performed a study to compare the efficacy of Vitamin D 3 oral solution with a conventional tablets and capsules in hypovitaminosis D patients. One hundred eighty subjects were divided into three different groups and received vitamin D 3 60000 IU per week for eight weeks either in the form of an oral solution or a tablet or a capsule. A significant increase in serum 25(OH)D was observed in vitamin D 3 oral solution from baseline (P=0.0001) as compared to a tablet (P=0.0001) and capsule (P=0.0001). A significant decrease in iPTH levels was seen in the vitamin D 3 oral solution group from baseline (P=0.0001) and also as compared to a tablet (P=0.0001) and capsule (P=0.0001). Oral solution of vitamin D 3 is a nanotechnology-based formulation which was found to be effective and safe. Thus, treatment with vitamin D 3 oral solution in hypovitaminosis D patients may result in faster and higher improvement in the normalization of vitamin D levels.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Krishnakumar M Nandgaye. 2020. \u201cEfficacy and Safety of Vitamin D3 (Cholecalciferol) Oral Solution Compared to Tablet and Capsule: A Randomized, Parallel-Design, Active-Controlled Study\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 20 (GJMR Volume 20 Issue B5): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification: NLMC Code: QV 701
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v1.2

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July 27, 2020

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English

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We performed a study to compare the efficacy of Vitamin D 3 oral solution with a conventional tablets and capsules in hypovitaminosis D patients. One hundred eighty subjects were divided into three different groups and received vitamin D 3 60000 IU per week for eight weeks either in the form of an oral solution or a tablet or a capsule. A significant increase in serum 25(OH)D was observed in vitamin D 3 oral solution from baseline (P=0.0001) as compared to a tablet (P=0.0001) and capsule (P=0.0001). A significant decrease in iPTH levels was seen in the vitamin D 3 oral solution group from baseline (P=0.0001) and also as compared to a tablet (P=0.0001) and capsule (P=0.0001). Oral solution of vitamin D 3 is a nanotechnology-based formulation which was found to be effective and safe. Thus, treatment with vitamin D 3 oral solution in hypovitaminosis D patients may result in faster and higher improvement in the normalization of vitamin D levels.

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Efficacy and Safety of Vitamin D3 (Cholecalciferol) Oral Solution Compared to Tablet and Capsule: A Randomized, Parallel-Design, Active-Controlled Study

Krishnakumar M Nandgaye
Krishnakumar M Nandgaye
Santoshi B. Kadam
Santoshi B. Kadam
Dr. Prashant J. Palkar
Dr. Prashant J. Palkar

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