Efficacy and Safety of Vitamin D3 (Cholecalciferol) Oral Solution Compared to Tablet and Capsule: A Randomized, Parallel-Design, Active-Controlled Study

Krishnakumar M Nandgaye; Santoshi B. Kadam; Dr. Prashant J. Palkar

Efficacy and Safety of Vitamin D3 (Cholecalciferol) Oral Solution Compared to Tablet and Capsule: A Randomized, Parallel-Design, Active-Controlled Study

Krishnakumar M Nandgaye *

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Santoshi B. Kadam

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Dr. Prashant J. Palkar

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Efficacy and Safety of Vitamin D3 (Cholecalciferol) Oral Solution Compared to Tablet and Capsule: A Randomized, Parallel-Design, Active-Controlled Study

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Abstract

We performed a study to compare the efficacy of Vitamin D 3 oral solution with a conventional tablets and capsules in hypovitaminosis D patients. One hundred eighty subjects were divided into three different groups and received vitamin D 3 60000 IU per week for eight weeks either in the form of an oral solution or a tablet or a capsule. A significant increase in serum 25(OH)D was observed in vitamin D 3 oral solution from baseline (P=0.0001) as compared to a tablet (P=0.0001) and capsule (P=0.0001). A significant decrease in iPTH levels was seen in the vitamin D 3 oral solution group from baseline (P=0.0001) and also as compared to a tablet (P=0.0001) and capsule (P=0.0001). Oral solution of vitamin D 3 is a nanotechnology-based formulation which was found to be effective and safe. Thus, treatment with vitamin D 3 oral solution in hypovitaminosis D patients may result in faster and higher improvement in the normalization of vitamin D levels.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Krishnakumar Nandgaye, Santoshi Kadam, Dr. Palkar. 2020. "Efficacy and Safety of Vitamin D3 (Cholecalciferol) Oral Solution Compared to Tablet and Capsule: A Randomized, Parallel-Design, Active-Controlled Study". Global Journal of Medical Research, Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 20 (GJMR Volume 20 Issue B5).

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GJMR Volume 20 Issue B5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-B Classification NLMC Code: QV 701

Submission ReceivedDecember 15, 2019
Peer Review Double Blind
Handling Editor
Accepted January 5, 2020
Published January 15, 2020

Version of record

v1.2

Issue date

July 27, 2020

Language

English

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