Efficacy Of Halofantrine In Mice Infected With Plasmodium berghei

Efficacy Of Halofantrine In Mice Infected With Plasmodium berghei

Dr. Ologunde

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C. A.

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Olaoye

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A. B.

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Olofinjana

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Akogun

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O. O.

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α The Federal Polytechnic, Ado-Ekiti

Efficacy Of Halofantrine In Mice Infected With Plasmodium berghei

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Abstract

Drug adulteration is commonly reported in Nigeria. Halofantrine purchased in four different locations in Ondo and Ekiti state, Nigeria were tested in mice for their comparative efficacy. The average parasite clearance time (PCT) were 4.4±0.49, 4.2±0.40, 4.4±0.80 and 4.2±0.75 for Halofantrine coded HAL-AK, HAL-IO, HAL-AD and HAL-IK respectively. Also, average parasite clearance rate (PCR) were 8653±2557, 6895±1010, 5426±1850 and 6226±1850 respectively. The result shows that there was no significant difference in the PCR (P>0.05) between the drugs. All the halofantrine drugscompletely cleared the parasites within 4-5 days. The results of this study indicates that adulteration of Halofantrine is not presently in circulation in areas of Ondo and Ekiti states, South Western Nigeria.

References

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr. Ologunde. 2012. \u201cEfficacy Of Halofantrine In Mice Infected With Plasmodium berghei\u201d. Global Journal of Medical Research - F: Diseases GJMR-F Volume 12 (GJMR Volume 12 Issue F3): .

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GJMR Volume 12 Issue F3
Pg. 1- 6

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Adulteration clearance rate halofantrine parasite clearance

Submission ReceivedDecember 6, 2011
Peer Review Double Blind
Handling Editor
Accepted January 4, 2012
Published January 15, 2012

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v1.2

Issue date

May 7, 2012

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Article Matrices

Total Score: 113

Country: Nigeria

Subject: Global Journal of Medical Research - F: Diseases

Authors: Dr. Ologunde, C. A., Olaoye, A. B., Olofinjana, O., Akogun, O. O. (PhD/Dr. count: 1)

View Count (all-time): 124

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Publish Date: 2012 05, Mon

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Total Views: 5490

Total Downloads: 2731

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