Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas

Dr. Reshma Venugopal; Dr. Radhika Manoj Bavle; Dr. Sudhakara Muniswamappa; Dr. Soumya Makarla

Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas

Dr. Reshma Venugopal * §

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Dr. Radhika Manoj Bavle

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Dr. Sudhakara Muniswamappa

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Dr. Soumya Makarla

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§ Krishnadevaraya College of Dental Sciences

Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas

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Abstract

Non-coding ribonucleic acids (ncRNAs) are a class of RNA molecules that are transcribed but not translated into proteins, but they affect various cellular processes. Around 60% of genes in humans do not code proteins but regulate target gene expression. Presently, a lot of research is carried out on ncRNA involvement in oral squamous cell carcinoma (OSCC) and its precursor lesions termed as oral potentially malignant disorders (OPMDs). They are broadly classified as small ncRNAs (sncRNA) and long ncRNAs (lncRNA). sncRNAs are extensively studied, whereas the divulgence of lncRNAs in OSCCs needs more revelation, hence reviewed in the present article. LncRNAs have a base pair length of more than 200, can form complex structures and influence the gene expression in a multifaceted pattern that attracts interest.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Dr. Venugopal, Dr. Bavle, Dr. Muniswamappa, Dr. Makarla. 2020. "Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas". Global Journal of Medical Research, Global Journal of Medical Research - J: Dentistry & Otolaryngology GJMR-J Volume 20 (GJMR Volume 20 Issue J5).

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GJMR Volume 20 Issue J5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-J Classification NLMC Code: QZ 365

Submission ReceivedDecember 12, 2019
Peer Review Double Blind
Handling Editor
Accepted January 4, 2020
Published January 15, 2020

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v1.2

Issue date

July 11, 2020

Language

English

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