Loading menu…

Epilepsy: The Next Generation Drugs (A Review)

Epilepsy: The Next Generation Drugs (A Review)

Article Fingerprint

ReserarchID

PDDTM1W96D

Epilepsy: The Next Generation Drugs (A Review) Banner

Key Research Insights

Synthesized scholarly intelligence & interactive research assistant
  • English
  • Afrikaans
  • Albanian
  • Amharic
  • Arabic
  • Armenian
  • Azerbaijani
  • Basque
  • Belarusian
  • Bengali
  • Bosnian
  • Bulgarian
  • Catalan
  • Cebuano
  • Chichewa
  • Chinese (Simplified)
  • Chinese (Traditional)
  • Corsican
  • Croatian
  • Czech
  • Danish
  • Dutch
  • Esperanto
  • Estonian
  • Filipino
  • Finnish
  • French
  • Frisian
  • Galician
  • Georgian
  • German
  • Greek
  • Gujarati
  • Haitian Creole
  • Hausa
  • Hawaiian
  • Hebrew
  • Hindi
  • Hmong
  • Hungarian
  • Icelandic
  • Igbo
  • Indonesian
  • Irish
  • Italian
  • Japanese
  • Javanese
  • Kannada
  • Kazakh
  • Khmer
  • Korean
  • Kurdish (Kurmanji)
  • Kyrgyz
  • Lao
  • Latin
  • Latvian
  • Lithuanian
  • Luxembourgish
  • Macedonian
  • Malagasy
  • Malay
  • Malayalam
  • Maltese
  • Maori
  • Marathi
  • Mongolian
  • Myanmar (Burmese)
  • Nepali
  • Norwegian
  • Pashto
  • Persian
  • Polish
  • Portuguese
  • Punjabi
  • Romanian
  • Russian
  • Samoan
  • Scots Gaelic
  • Serbian
  • Sesotho
  • Shona
  • Sindhi
  • Sinhala
  • Slovak
  • Slovenian
  • Somali
  • Spanish
  • Sundanese
  • Swahili
  • Swedish
  • Tajik
  • Tamil
  • Telugu
  • Thai
  • Turkish
  • Ukrainian
  • Urdu
  • Uzbek
  • Vietnamese
  • Welsh
  • Xhosa
  • Yiddish
  • Yoruba
  • Zulu
Reading Preferences
Font Size
Line Spacing
Background
This converted HTML version may contain rendering inconsistencies. Please refer to the PDF for the authoritative version, or click here to provide feedback.

Abstract

Seizures are common and are treated in all branches of medicine. Approximately 10% of the population will have one or more seizures during their lifetime. Seizures are symptoms that occur in acute illness, ie, provoked seizures, or in epilepsy, ie, unprovoked seizures. Antiepileptic drugs (AEDs) are pharmacologic agents used to reduce the frequency of epileptic seizures. “Antiepileptic” drug is a misnomer, because these drugs are effective as symptomatic treatment of seizures, i.e., the symptoms of epilepsy, not as treatment of epilepsy itself. Recent discoveries in molecular biology and genetics have elucidated a genetic basis for some epilepsy syndromes, which will lead to new treatments. This review include new AEDs viz; Ganaxolone, Eslicarbazepine acetate, Fluorofel-bamate, Huperzine A, Carisbamate (RWJ-333369), Brivaracetam (ucb 34714), 2-Deoxy-D-glucose, Retigabine, T2000 , T2007, Valrocemide, Tonabersat (SB-220453), YKP3089, Propyl isopropyl acetamide, JZP-4, ICA-105665, NAX-5055, Perampanel and Valpromide.

References

40 Cites in Article
  1. 1. Hauser WA,Annegers JF,Rocca WA (1996). Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota. Mayo Clin Proc, 71, 576-86.
  2. 2. Armin Haerer,Dallas Anderson,Bruce Schoenberg (1986). Prevalence and clinical features of epilepsy in a biracial United States population Epilepsia. Epilepsia, 27(1), 66-75.
  3. 3. Hauser WA,Annegers JF,Rocca WA (1996). Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota. Mayo Clin Proc, 71, 578-86.
  4. 4. Hauser WA,Annegers JF,Kurland LT (1991). The prevalence of epilepsy in Rochester, Minnesota: 1940-1980 Epilepsia. Epilepsia, 32, 429-445.
  5. 5. Hauser WA,Annegers JF,Kurland LT (1993). Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984 Epilepsia. Epilepsia, 34, 453-468.
  6. 6. John Annegers,Walter Rocca,W. Hauser (1996). Causes of epilepsy: contributions of the Rochester epidemiology project Mayo Clin Proc. Mayo Clinic Proceedings, 71(6), 570-575.
  7. 7. Giller Nohria V,Ganaxolone (2004). Ganaxolone. Neurotherapeutics, 4, 102-105.
  8. 8. Carter R.B,Wood P.L,Wieland S,Hawkinson J.E,Belelli D,Lambert J.J,White H.S,Wolf H.H,Mirsadeghi S,Tahir S.H,Bolger M.B,Lan N.C,Gee K.W (1997). Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3(-hydroxy-3(- methyl-5(-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acidA receptor. J. Pharmacol. Exp. Ther, 280, 1284 1295.
  9. 9. M. Le´skiewicz,B. Budziszewska,L. Jaworska-Feil,M. Kubera,W. Basta-Kaim Lason (2003). Le´skiewicz M, Budziszewska B, Jaworska-Feil L, Kubera M, Basta-Kaim Lason W, Inhibitory effect of some neuroactive steroids on cocaine-induced kindling in mice. Polish J. Pharmacol, 55, 1131-1136.
  10. 10. M. Rogawski,D. Reddy (2004). Neurosteroids: endogenous modulators of seizure susceptibility In: Rho, J.M., Sankar, R., Cavazos, J (Eds.), Epilepsy: Scientific Foundations of Clinical Practice. Marcel Dekker, 319-355.
  11. 11. Baldelli Biagini G,Pradelli Longo D,Zini I,Avoli Rogawski M.A (2006). Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy. Exp. Neurol, 201, 519-524.
  12. 12. A. Freitas (1999). Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide Derivatives. P, Learmonth D.A, Cunha R.A, Garrett J, Soares-da-Silva P, Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro- 5H-dibenz [b,f] azepine-5-carboxamide derivatives. J. Med. Chem, 42, 2582-2587.
  13. 13. Ambrosio,Silva Araujo,I.,Malva Soaresda- Silva,P. Carvalho,A. Carvalho,C. (2000). Neurotoxic/ neuroprotective profile of carbamazepine, oxcarba-zepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2- 024. Eur. J. Pharmacol, 406, 191-201.
  14. 14. Cunha R.A,Coelho J.E,Costenla A.R,Parada Lopes L.V,de A,Sebastiao A.M,Ribeiro J.A,Effects carbamazepine (2002). Effects of carbamazepine and novel 10,11- dihydro-5H dibenz[b,f]azepine- 5-carboxamide derivatives on synaptic transmission in rat hippocampal slices. Pharmacol. Toxicol, 90, 208-213.
  15. 15. Soares-da-Silva Almeida L (2007). Eslicarbazepine Acetate (BIA 2-093). Neurotherapeutics, 4, 88-96.
  16. 16. Ward J,Caprio V (2006). A radical mediated approach to the core structure of Huperzine A. Tetrahedron Lett, 47, 553-556.
  17. 17. Bialer M,Johannessen S.I,Kupferberg H.J,Perucca Levy R.H,Tomson T (2004). Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII).
  18. 18. Wallis Panizzon,K. Niquet,J. Masaratis,L. Baldwin,R. Wasterlain,C. (2000). Wallis R.A, Panizzon K.L, Niquet J, Masaratis L, Baldwin R, Wasterlain C.G, Neuroprotective effects of the anticonvulsant, fluorofelbamate. Epilepsia, 41(7), 162.
  19. 19. H. White,S. Schachter,D. Lee,J. Xiaoshen,D. Eisenberg (2005). White H.S, Schachter S, Lee D, Xiaoshen J, Eisenberg D, Anticonvulsant activity of Huperzine A, an alkaloid extract of Chinese club moss (Huperzia serrata). Epilepsia, 46(8), 220.
  20. 20. A. Zangara (2003). The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer’s disease. Pharmacol. Biochem. Behav, 75, 675-686.
  21. 21. H. White,A. Srivastava,B. Klein (2006). White H, Srivastava A, Klein B et al, The novel investigational neuromodulator RWJ-333369 displays a broad-spectrum anticonvulsant profile in rodent seizure and epilepsy models (abstract). Epilepsia
  22. 22. Grabenstatter H.L,Dudek F.E,A. AED,carisbamate (2008). A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate‐induced epilepsy. Epilepsia, 49, 1787-1794.
  23. 23. Niespodziany I,Leclere N,Matagne A,Wolff C (2009). Brivaracetam modulates Na+ currents expressed in a neuroblastoma cell line compared with carbamazepine. Epilepsia, 50, 107.
  24. 24. Matagne Kaminski R.M,Gillard Leclercq K,Kenda Michel P,Klitgaard Talaga P,generalized epilepsy (2008). SV2A protein is a broad-spectrum anticonvulsant target: Functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy. Neuropharmacology, 54, 715-720.
  25. 25. Matagne A,Kenda Margineanu D.G,Klitgaard Michel P,Anti-convulsive (2008). Anti‐convulsive and anti‐epileptic properties of brivaracetam (ucb 34714), a high‐affinity ligand for the synaptic vesicle protein, SV2A. 2008a, 154, 1662-1671.
  26. 26. Johnston Berwick J,Martindale Jones M,Kennerly Martin C,Redgrave P,Mayhew J.E (2008). Fine detail of neurovascular coupling revealed by spatio-temporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex. J. Neurophysiol, 99, 787-798.
  27. 27. Netzer Rundfeldt C (2000). The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits. Neurosci. Lett, 282, 73-76.
  28. 28. Yagen Spiegelstein O,Bialer M (1999). Epile-psia.1999. Epilepsia, 40, 545-552.
  29. 29. M. Bialer,S. Johannessen,H. Kupferberg,R. Levy,P. Loiseau,E. Perucca (2001). Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V).
  30. 30. M. Bialer,S. Johannessen,H. Kupferberg,R. Levy,P. Loiseau,E. Perucca (2002). Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI).
  31. 31. Bialer M,Johannessen S.I,Kupferberg H.J,Perucca Levy R.H,Tomson T (2004). Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII).
  32. 32. Bingham Parsons A.A,Read Raval P,Upton Thompson M (2001). Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve induced neurovascular reflexes. Br. J. Pharmacol, 132, 1549-1557.
  33. 33. Bialer M,Johannessen S.I,Kupferberg H.J,Perucca Levy R.H,Tomson T (2010). Progress report on new antiepileptic drugs: A summary of the Tenth Eilat Conference (EILAT X).
  34. 34. Bialer M,Clinical valpromide (1991). Clinical pharmacology of valpromide. Clin. Pharmacokinet, 20, 114-122.
  35. 35. Johannessen Bialer M,Kupferberg H.J,Perucca Levy R.H,Tomson T (2007). Progress report on new antiepileptic drugs: A summary of the Eigth Eilat Conference (EILAT VIII).
  36. 36. A. Funk,R. Ricci,Anderson,Arana De Colle,C.,Wang,George (2008). Single doses of JZP- 4 decrease cortical excitability. A transcranial magnetic stimulation study. American Epilepsy Society 2008 Annual Meeting
  37. 37. Binnie C.D,Kasteleijn-Nolst D.G.A,De R.A (1986). Photosensitivity as a model for acute antiepileptic drug studies. Electroencephalogr. Clin. Neurophysiol, 63, 35-41.
  38. 38. H. White,Erika Scholl,Brian Klein,Sean Flynn,Timothy Pruess,Brad Green,Liuyin Zhang,Grzegorz Bulaj (2009). Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically active galanin analog, in epilepsy models Neurotherapeutics. Neurotherapeutics, 6(2), 372-380.
  39. 39. Y. Hashizume,T. Hanada,A. Ogasawara,M. Ueno,Y. Nishizawa (2008). Anticonvulsant activity of perampanel, a selective AMPA receptor antagonist, in rodent models of epileptic seizure. Poster P02.113 presented at the 60th Annual Meeting of the American Academy of Neurology
  40. 40. G. Shaltiel,M. Shirley,Ora Belmaker,R. Agam,G. (2007). Effect of valproate derivatives on human brain myo-inositol-1-phosphate (MIP) synthase activity and amphetamine-induced rearing. Pharmacol. Report, 59, 402-407.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Amit Kumar Shrivastava, Manish Dhar Dwivedi, gulzar_alam. 2014. "Epilepsy: The Next Generation Drugs (A Review)". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue 28 (B4)).

More Citation Formats

Download Citation

Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
Classification
GJMR-B Classification NLMC Code: WL 385
WM 402
Version of record
v1.2

Issue date
June 19, 2014

Language
English
Order Article Reprint
Experience in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

Article Matrices
Total Views: 1.1K
Total Downloads: 63
All Trends

Request Access

Please fill out the form below to request access to this research paper. Your request will be reviewed by the editorial or author team.
X

This is the heading

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

High-quality academic research articles on global topics and journals.

Epilepsy: The Next Generation Drugs (A Review)

Amit Shrivastava
Amit Shrivastava
Manish Dwivedi
Manish Dwivedi