Erythrocyte membrane lipid alteration in type 2 Diabetic subjects

1
grudrappa
grudrappa
2
Basavaraj Aski
Basavaraj Aski
3
Kashinath.R.T
Kashinath.R.T
1 Basaveshwara Medical College & Hospital / rajiv Gandhi University of Health Sciences

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The lipid components present in biological membranes including erythrocyte membrane are significant in regulation of the membrane fluidity as well as transport across the membranes. The conflicting results of either increase or decrease or no change have been reported in erythrocyte membrane fluidity in type 2 diabetic subjects. The diabetes induced dyslipidemia possibly lead to an alteration in erythrocyte membrane lipid composition. Hence a study was undertaken to assess erythrocyte membrane lipid alterations in type 2 diabetic subjects. The blood samples from randomly selected type 2 diabetic subjects, attending Medical OPD of Basaveshwara Medical College Hospital, Chitradurga, were collected with heparin as an anticoagulant. Erythrocyte membrane total cholesterol (mTC), Erythrocyte membrane phospholipids (mPL), Erythrocyte membrane phosphatidyl choline, Erythrocyte membrane sphingomyelin and Erythrocyte membrane phospholipids/ Erythrocyte membrane cholesterol ratio were studied. The results suggests a significant rise in erythrocyte membrane cholesterol (mTC, N=1.25±0.31, T2DM= 1.54± 0.14, p

30 Cites in Articles

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Funding

No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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grudrappa. 1970. \u201cErythrocyte membrane lipid alteration in type 2 Diabetic subjects\u201d. Unknown Journal GJMR Volume 11 (GJMR Volume 11 Issue 3): .

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The lipid components present in biological membranes including erythrocyte membrane are significant in regulation of the membrane fluidity as well as transport across the membranes. The conflicting results of either increase or decrease or no change have been reported in erythrocyte membrane fluidity in type 2 diabetic subjects. The diabetes induced dyslipidemia possibly lead to an alteration in erythrocyte membrane lipid composition. Hence a study was undertaken to assess erythrocyte membrane lipid alterations in type 2 diabetic subjects. The blood samples from randomly selected type 2 diabetic subjects, attending Medical OPD of Basaveshwara Medical College Hospital, Chitradurga, were collected with heparin as an anticoagulant. Erythrocyte membrane total cholesterol (mTC), Erythrocyte membrane phospholipids (mPL), Erythrocyte membrane phosphatidyl choline, Erythrocyte membrane sphingomyelin and Erythrocyte membrane phospholipids/ Erythrocyte membrane cholesterol ratio were studied. The results suggests a significant rise in erythrocyte membrane cholesterol (mTC, N=1.25±0.31, T2DM= 1.54± 0.14, p

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Erythrocyte membrane lipid alteration in type 2 Diabetic subjects

Basavaraj Aski
Basavaraj Aski
Kashinath.R.T
Kashinath.R.T

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