Erythrocyte membrane lipid alteration in type 2 Diabetic subjects

Basavaraj Aski; Kashinath.R.T

Erythrocyte membrane lipid alteration in type 2 Diabetic subjects

Dr. Rudrappa G * §

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Dr. Basavaraj Aski ‡

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Dr. Kashinath.R.T ¶ Msc Biochemistry, Ph.D. Biochemistry (Medical Faculty), FICS

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§ Basaveshwara Medical College & Hospital / rajiv Gand...

‡ BLDE (Deemed to be University)

¶ Rajiv Gandhi University of Health Sciences

Erythrocyte membrane lipid alteration in type 2 Diabetic subjects

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Abstract

The lipid components present in biological membranes including erythrocyte membrane are significant in regulation of the membrane fluidity as well as transport across the membranes. The conflicting results of either increase or decrease or no change have been reported in erythrocyte membrane fluidity in type 2 diabetic subjects. The diabetes induced dyslipidemia possibly lead to an alteration in erythrocyte membrane lipid composition. Hence a study was undertaken to assess erythrocyte membrane lipid alterations in type 2 diabetic subjects. The blood samples from randomly selected type 2 diabetic subjects, attending Medical OPD of Basaveshwara Medical College Hospital, Chitradurga, were collected with heparin as an anticoagulant. Erythrocyte membrane total cholesterol (mTC), Erythrocyte membrane phospholipids (mPL), Erythrocyte membrane phosphatidyl choline, Erythrocyte membrane sphingomyelin and Erythrocyte membrane phospholipids/ Erythrocyte membrane cholesterol ratio were studied. The results suggests a significant rise in erythrocyte membrane cholesterol (mTC, N=1.25±0.31, T2DM= 1.54± 0.14, p

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr., Dr. Basavaraj Aski, Dr. Kashinath.R.T. 1970. "Erythrocyte membrane lipid alteration in type 2 Diabetic subjects". Global Journal of Medical Research GJMR Volume 11 (GJMR Volume 11 Issue 3).

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GJMR Volume 11 Issue 3

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

membrane cholessterol membrane Phospholipids/ cholesterol ratio membrane phosplipids

Submission ReceivedJuly 20, 2011
Peer Review Double Blind
Handling Editor
Accepted August 10, 2011
Published September 7, 2011

Version of record

v1.2

Issue date

September 7, 2011

Language

English

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Total Score: 142

Country: India

Subject: Global Journal of Medical Research

Authors: Basavaraj Aski, Kashinath.R.T (PhD/Dr. count: 0)

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Publish Date: 2011 08, Tue

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