Evaluating Hydrocolloids of Sida Acuta as Sustained Release Matrix for Ibuprofen Tablet
Background and Objectives: Matrix tablet formulation for ibuprofen using natural hydrocolloids are a good alternative to conventional ibuprofen immediate-release tablet and would be a desired option as opposed to the use of synthetic polymer. This work was to prepare and evaluate sustained-release ibuprofen matrix tablets using Sida acuta gum. Guar gum is the reference natural polymer. Materials and Methods: Sida gum was obtained from aqueous macerate of Sida acuta leaves then precipitated using acetone, whereas guar gum was purchased. Both gums were characterized for micromeritics, swelling properties, and hydration capacities. The granules of ibuprofen, using a gum for a separate batch, were prepared by wet granulation method. The matrix tablets were produced, physical properties determined, and dissolution studies carried out. The release kinetics values obtained were fit into equations for kinetic studies.
