Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

1
Hassan M.F.Madkour
Hassan M.F.Madkour
2
Dr. Nizam Baloch
Dr. Nizam Baloch
3
Yasser M.S.A.Alkahraman
Yasser M.S.A.Alkahraman
4
Mudassir A.Zaidi
Mudassir A.Zaidi
1 University of Balochistan, Quetta, Pakistan and Ain Shams University, Cairo, Egypt.

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The present work aims at study of antileishmanial activity of some 6, 8-dichloro-2methyl-4H-chromen-4-one derivatives. The synthesized chromenes have been screened for antileishmanial activity on L. major parasite. The results were promising and showed that all compounds under investigation have some degree of activity against leishmania L. major parasite and compound 5 showed potential activity with IC 50 value 0.58± 0.09 μg/ml, comparatively with the standard drug Amphotericin B.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Hassan M.F.Madkour. 2012. \u201cEvaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 12 (GJSFR Volume 12 Issue B7): .

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GJSFR Volume 12 Issue B7
Pg. 27- 32
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Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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December 8, 2012

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English

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The present work aims at study of antileishmanial activity of some 6, 8-dichloro-2methyl-4H-chromen-4-one derivatives. The synthesized chromenes have been screened for antileishmanial activity on L. major parasite. The results were promising and showed that all compounds under investigation have some degree of activity against leishmania L. major parasite and compound 5 showed potential activity with IC 50 value 0.58± 0.09 μg/ml, comparatively with the standard drug Amphotericin B.

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Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

Dr. Nizam Baloch
Dr. Nizam Baloch
Yasser M.S.A.Alkahraman
Yasser M.S.A.Alkahraman
Mudassir A.Zaidi
Mudassir A.Zaidi
Hassan M.F.Madkour
Hassan M.F.Madkour University of Balochistan, Quetta, Pakistan and Ain Shams University, Cairo, Egypt.

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