Evaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice

1
D. Yashwanth Kumar
D. Yashwanth Kumar
2
Krishna Prasad.D
Krishna Prasad.D
3
S.N. Sri Harsha
S.N. Sri Harsha
4
K.S.S.N. Neelima
K.S.S.N. Neelima
1 PACIFIC University,

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Murraya koenigii Spreng (Rutaceae), a medicinally important herb of Indian origin, has been Used for centuries in the Ayurvedic System of Medicine. Aqueous extract of the leaves of Murraya koenigii possesses alexeteric, antihelmintic, analgesic, dysentry, purgative and blood disorders. Also they are reported to be useful in inflammation, healing of wounds, injuries, antioxidative activity. In folklore practice, the decoction of M. koenigii leaves has been reported to be useful in diarrhoea. In the present study the effect of hydroalcoholic extract of seeds was evaluated for antidepressant activity in mice. The models selected for the study were tail suspension test and despair swimming test. The extract at the doses of 100mg/kg, 250mg/kg and 500mg/kg significantly reduced the duration of immobility of mice in tail suspension test and despair swimming test as compared to the untreated group.

19 Cites in Articles

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

D. Yashwanth Kumar. 2014. \u201cEvaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice\u201d. Global Journal of Medical Research - G: Veterinary Science & Medicine GJMR-G Volume 13 (GJMR Volume 13 Issue G2): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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January 29, 2014

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English

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Murraya koenigii Spreng (Rutaceae), a medicinally important herb of Indian origin, has been Used for centuries in the Ayurvedic System of Medicine. Aqueous extract of the leaves of Murraya koenigii possesses alexeteric, antihelmintic, analgesic, dysentry, purgative and blood disorders. Also they are reported to be useful in inflammation, healing of wounds, injuries, antioxidative activity. In folklore practice, the decoction of M. koenigii leaves has been reported to be useful in diarrhoea. In the present study the effect of hydroalcoholic extract of seeds was evaluated for antidepressant activity in mice. The models selected for the study were tail suspension test and despair swimming test. The extract at the doses of 100mg/kg, 250mg/kg and 500mg/kg significantly reduced the duration of immobility of mice in tail suspension test and despair swimming test as compared to the untreated group.

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Evaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice

Krishna Prasad.D
Krishna Prasad.D
S.N. Sri Harsha
S.N. Sri Harsha
D. Yashwanth Kumar
D. Yashwanth Kumar PACIFIC University,
K.S.S.N. Neelima
K.S.S.N. Neelima

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