Evaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice

D. Yashwanth Kumar

Evaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice

D. Yashwanth Kumar * §

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§ PACIFIC University

Evaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice

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Abstract

Murraya koenigii Spreng (Rutaceae), a medicinally important herb of Indian origin, has been Used for centuries in the Ayurvedic System of Medicine. Aqueous extract of the leaves of Murraya koenigii possesses alexeteric, antihelmintic, analgesic, dysentry, purgative and blood disorders. Also they are reported to be useful in inflammation, healing of wounds, injuries, antioxidative activity. In folklore practice, the decoction of M. koenigii leaves has been reported to be useful in diarrhoea. In the present study the effect of hydroalcoholic extract of seeds was evaluated for antidepressant activity in mice. The models selected for the study were tail suspension test and despair swimming test. The extract at the doses of 100mg/kg, 250mg/kg and 500mg/kg significantly reduced the duration of immobility of mice in tail suspension test and despair swimming test as compared to the untreated group.

References

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

D. Kumar. 2014. "Evaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice". Global Journal of Medical Research, Global Journal of Medical Research - G: Veterinary Science & Medicine GJMR-G Volume 13 (GJMR Volume 13 Issue G2).

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GJMR Volume 13 Issue G2

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

anti depressant activity aqueous extract mice murraya koenigii (mk)

Classification

GJMR-G Classification NLMC Code: WD 730

WL 108

Submission ReceivedDecember 8, 2012
Peer Review Double Blind
Handling Editor
Accepted January 4, 2013
Published January 15, 2013

Version of record

v1.2

Issue date

January 29, 2014

Language

English

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Article Matrices

Total Score: 144

Country: India

Subject: Global Journal of Medical Research

Authors: Krishna Prasad.D, S.N. Sri Harsha, D. Yashwanth Kumar, K.S.S.N. Neelima (PhD/Dr. count: 0)

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