Evaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice

Evaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice

D. Yashwanth Kumar

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Krishna Prasad.D

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S.N. Sri Harsha

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K.S.S.N. Neelima

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Pacific University

Evaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice

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Abstract

Murraya koenigii Spreng (Rutaceae), a medicinally important herb of Indian origin, has been Used for centuries in the Ayurvedic System of Medicine. Aqueous extract of the leaves of Murraya koenigii possesses alexeteric, antihelmintic, analgesic, dysentry, purgative and blood disorders. Also they are reported to be useful in inflammation, healing of wounds, injuries, antioxidative activity. In folklore practice, the decoction of M. koenigii leaves has been reported to be useful in diarrhoea. In the present study the effect of hydroalcoholic extract of seeds was evaluated for antidepressant activity in mice. The models selected for the study were tail suspension test and despair swimming test. The extract at the doses of 100mg/kg, 250mg/kg and 500mg/kg significantly reduced the duration of immobility of mice in tail suspension test and despair swimming test as compared to the untreated group.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

D. Yashwanth Kumar. 2014. \u201cEvaluation of Anti Depressant Activity of Murraya Koenigii Leaf Extract in Mice\u201d. Global Journal of Medical Research - G: Veterinary Science & Medicine GJMR-G Volume 13 (GJMR Volume 13 Issue G2).

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GJMR Volume 13 Issue G2

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

anti depressant activity aqueous extract mice murraya koenigii (mk)

Submission ReceivedDecember 8, 2012
Peer Review Double Blind
Handling Editor
Accepted January 4, 2013
Published January 15, 2013

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v1.2

Issue date

January 29, 2014

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Article Matrices

Total Score: 104

Country: India

Subject: Global Journal of Medical Research - G: Veterinary Science & Medicine

Authors: Krishna Prasad.D, S.N. Sri Harsha, D. Yashwanth Kumar, K.S.S.N. Neelima (PhD/Dr. count: 0)

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Total Downloads: 2414

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