Evaluation of total phenolic contents and antiulcerogenic activity of root bark of Azadirachta indica

Mohammed Ibrahim

Evaluation of total phenolic contents and antiulcerogenic activity of root bark of Azadirachta indica

Mohammed Ibrahim * §

Contact

§ Nizam Institute of Pharmacy

Evaluation of total phenolic contents and antiulcerogenic activity of root bark of Azadirachta indica

Article Fingerprint

ReserarchID

MR41YII

Evaluation of total phenolic contents and antiulcerogenic activity of root bark of Azadirachta indica Banner

AI TAKEAWAY

Connecting with the Eternal Ground

Abstract

The effect of methanol extract of root bark of Azadirachta indica was investigated in mice to evaluate the antiulcerogenic activity. Total phenolics were also determined. The root Extracts were subjected to phytochemical analysis and total phenolics were also determined by the modified Folin-Ciocalteu method. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, pH, free acidity, total acidity, and ulcer index and % ulcer protection. The results indicated that the methanol extract significantly (p< 0.001) decreases volume of gastric acid secretion, pH, free acidity, total acidity and ulcer index and shows significant ulcer protection compared to standard control. Root bark extracts found to possess significant amount of phenolics and other biologically active constituents based on phytochemical evaluation and shows significant antiulcerogenic activity.

References

35 Cites in Article

Reference Format

R Chopra,I Chopra (1995). A review of work on Indian medicinal plants including indigenous drugs and poisonous plants. Indian council of medical research.
N Pillai,D Suganthan,C Seshadri,Santha Kumara G (1978). Antigastric activity of nimbidin Indian.
V Balakrishnan,M Narendranathan,A Subair,E Raji,N Pillai,Santha Kumara G (1985). Nimbidin in duodenal ulcer.
H Schmutterer (1995). In the neem tree edited by Schmutterer H Weinheim federal republic of Germany.
R Subapriya,S Nagini (2005). Medicinal properties of neem leaves: a review.
Kausik Biswas,Ishita Chattopadhyay,K Ranajit,Uday Banerjee,Bandyopadhyay (2002). Biological activities and medicinal properties of neem (Azadirachta indica).
M Aktar,Dwaipayan Sengupta (2008). Neem: A great boon to mankind www.
P Dandiya,S Kulkarni (2005). Introduction to.
J Belaiche,A Burette,M Devos,E Louis,M Huybrechts,M Dettenre (2002). Observation survey of NSAID related upper gastrointestinal adverse events in Belgium.
P Dharmani (2006). Pallt G Exploring Indian medicinal plants for antiulcer activity.
I Chopra,K Gupta,B Nair (1952). Preliminary study of antibacterial substances from Melia azadirachta Indian.
Werner Fabry,Paul Okemo,Rainer Ansorg (1996). Activity of East African Medicinal Plants against Helicobacter pylori.
S Pogtip,S Roongtawan,G Wandee (2005). Antioxidant activity of Saimese neem tree.
U Bandyopadhyay,R Chatterjee,R Bandyopadhyay (1998). Unknown Title.
G Garg,S Nigam,C Ogle (1993). The Gastric Antiulcer Effects of the Leaves of theNeemTree.
M Kiranmai,M Ibrahim,Mahendra Kumar,C (2011). Free radical scavenging activity of neem tree root bark extract Asia.
K Asha,R Chowdhury,M Choudhury,M Rashid (2004). Steroids and polyketides from Uvaria hamiltonii stem bark.
P Ashokkumar,Rajkumar,M Kanimozhi (2010). Phytochemical screening and antimicrobial activity from five Indian medicinal plants against human pathogens.
H (2004). Male Thin-layer chromatographic analysis of flavonoids, phenolic acids, and amino acids in some Croatian Hypericum taxa.
Vernon Singleton,Rudolf Orthofer,Rosa Lamuela-Raventós (1999). [14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent.
Joe Vinson,Ligia Zubik,Pratima Bose,Najwa Samman,John Proch (2005). Dried Fruits: Excellentin Vitroandin VivoAntioxidants.
K Wolfe,X Wu (2003). Liu RH Antioxidant activity of apple peels.
P Malairajan,Geetha Gopalakrishnan,S Narasimhan,Kjessi Veni (2008). Evalution of anti-ulcer activity of Polyalthia longifolia (Sonn.) Thwaites in experimental animals.
N Gill,S Dhawan,A Jain,R Arora,M Bali (2012). Antioxidant and Anti-Ulcerogenic Activity of Wild Punica granatum Ethanolic Seed Extract.
Kh,Cheesman (1993). Lipid peroxidation in biological systems in DNA and free radicals.
J Desai,R Goyal,N Parmar (1997). Pathogenesis of peptic ulcer disease and current trends in therapy.
Szabo,G Brown,H Pinam,J Dli,Newmeyer (1985). Duodenal ulcer induced by MPTP (1-methyl 4methyl 1,2,3,6,-tetrahydropyridine).
C Cho,B Chen,Y Poon,M Ng,W Hui,S Lam,C Ogle (1989). Dual Effects of Zinc Sulphate on Ethanol-induced Gastric Injury in Rats: Possibly Mediated by an Action on Mucosal Blood Flow.
Av,D Patel,R Santani,Goel (2000). Antiulcer activity and the mechanism of action of magaldrate in gastric ulceration models of rats.
L Hay,R Varco,C Code (1942). The experimental production of gastric and duodenal ulcers in laboratory animals by the intramuscular injection of histamine in beeswax.
S Walpole,R Varco,C Code,O Wangensteen (1940). Production of Gastric and Duodenal Ulcers in the Gat by Intramuscular Implantation of Histamine..
Lr (1917). Dragstedt: Contributions to the physiology of the stomach. XXXVII. Gastric juice in duodenal and gastric ulcers.
Muriel Barros,Marivane Lemos,Edson Maistro,Mateus Leite,João Sousa,Jairo Bastos,Sérgio Andrade (2008). Evaluation of antiulcer activity of the main phenolic acids found in Brazilian Green Propolis.
Ahmet Kahraman,Nilüfer Erkasap,Tülay Köken,Mustafa Serteser,Fatma Aktepe,Serdar Erkasap (2003). The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions.
D Lewis,P Hanson (1991). 4 Anti-Ulcer Drugs of Plant Origin.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Mohammed Ibrahim. . "Evaluation of total phenolic contents and antiulcerogenic activity of root bark of Azadirachta indica". Global Journal of Medical Research - I: Surgeries & Cardiovascular System GJMR-I Volume 12 (GJMR Volume 12 Issue I6).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 12 Issue I6

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

antiulcerogenic activity Azadirachta indica Methanol extract Omeprazole Root bark Total phenolics

Classification

GJMR-I Classification NLMC Code: QV 223

Submission ReceivedMay 18, 2012
Peer Review Double Blind
Handling Editor
Accepted June 12, 2012
Published June 23, 2012

Version of record

v1.2

Language

English

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 150

Country: India

Subject: Global Journal of Medical Research

Authors: Dr. M.Kiranmai, B.Usha Sri, D.Sudharshan Reddy, CB.Mahendra Kumar, Mohammed Ibrahim (PhD/Dr. count: 1)

View Count (all-time): 197

Total Views (Real + Logic): 7588

Total Downloads (simulated): 446

Publish Date: 2012 06, Sat

Monthly Totals (Real + Logic):

Month 1: 45 views
Month 2: 33 views
Month 3: 42 views
Month 4: 52 views
Month 5: 23 views
Month 6: 31 views
Month 7: 49 views
Month 8: 55 views
Month 9: 29 views
Month 10: 25 views
Month 11: 46 views
Month 12: 24 views
Month 13: 34 views
Month 14: 36 views
Month 15: 38 views
Month 16: 29 views
Month 17: 39 views
Month 18: 30 views
Month 19: 18 views
Month 20: 10 views
Month 21: 14 views
Month 22: 23 views
Month 23: 28 views
Month 24: 23 views
Month 25: 21 views
Month 26: 17 views
Month 27: 24 views
Month 28: 31 views
Month 29: 25 views
Month 30: 31 views
Month 31: 36 views
Month 32: 33 views
Month 33: 27 views
Month 34: 32 views
Month 35: 30 views
Month 36: 15 views
Month 37: 34 views
Month 38: 23 views
Month 39: 30 views
Month 40: 23 views
Month 41: 22 views
Month 42: 11 views
Month 43: 19 views
Month 44: 20 views
Month 45: 39 views
Month 46: 32 views
Month 47: 38 views
Month 48: 22 views
Month 49: 22 views
Month 50: 27 views
Month 51: 42 views
Month 52: 15 views
Month 53: 37 views
Month 54: 40 views
Month 55: 26 views
Month 56: 18 views
Month 57: 48 views
Month 58: 38 views
Month 59: 36 views
Month 60: 33 views
Month 61: 21 views
Month 62: 33 views
Month 63: 19 views
Month 64: 41 views
Month 65: 26 views
Month 66: 11 views
Month 67: 34 views
Month 68: 27 views
Month 69: 33 views
Month 70: 14 views
Month 71: 36 views
Month 72: 20 views
Month 73: 34 views
Month 74: 35 views
Month 75: 36 views
Month 76: 31 views
Month 77: 39 views
Month 78: 18 views
Month 79: 45 views
Month 80: 19 views
Month 81: 13 views
Month 82: 46 views
Month 83: 14 views
Month 84: 15 views
Month 85: 22 views
Month 86: 27 views
Month 87: 25 views
Month 88: 29 views
Month 89: 43 views
Month 90: 12 views
Month 91: 42 views
Month 92: 30 views
Month 93: 32 views
Month 94: 38 views
Month 95: 37 views
Month 96: 22 views
Month 97: 31 views
Month 98: 19 views
Month 99: 22 views
Month 100: 23 views
Month 101: 40 views
Month 102: 35 views
Month 103: 49 views
Month 104: 27 views
Month 105: 37 views
Month 106: 35 views
Month 107: 29 views
Month 108: 33 views
Month 109: 14 views
Month 110: 35 views
Month 111: 37 views
Month 112: 33 views
Month 113: 36 views
Month 114: 28 views
Month 115: 19 views
Month 116: 22 views
Month 117: 33 views
Month 118: 33 views
Month 119: 18 views
Month 120: 28 views
Month 121: 15 views
Month 122: 24 views
Month 123: 28 views
Month 124: 18 views
Month 125: 33 views
Month 126: 38 views
Month 127: 24 views
Month 128: 35 views
Month 129: 27 views
Month 130: 32 views
Month 131: 24 views
Month 132: 39 views
Month 133: 32 views
Month 134: 32 views
Month 135: 34 views
Month 136: 17 views
Month 137: 21 views
Month 138: 23 views
Month 139: 27 views
Month 140: 24 views
Month 141: 19 views
Month 142: 30 views
Month 143: 27 views
Month 144: 33 views
Month 145: 33 views
Month 146: 30 views
Month 147: 42 views
Month 148: 35 views
Month 149: 30 views
Month 150: 36 views
Month 151: 33 views
Month 152: 17 views
Month 153: 35 views
Month 154: 44 views
Month 155: 21 views
Month 156: 32 views
Month 157: 35 views
Month 158: 41 views
Month 159: 34 views
Month 160: 42 views
Month 161: 25 views
Month 162: 14 views
Month 163: 27 views
Month 164: 19 views
Month 165: 20 views
Month 166: 36 views
Month 167: 39 views
Month 168: 45 views
Month 169: 44 views
Month 170: 38 views
Month 171: 38 views
Month 172: 29 views

Total Views: 7.6K

Total Downloads: 446

All Trends