FLUOXETINE BIOEQUIVALENCE STUDY: QUANTIFICATION OF FLUOXETINE BY LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY

Abstract

A liquid chromatography method was developed and validated for the determination of fluoxetine in human plasma using paroxetine as internal standard. The drugs were extracted from plasma by liquid-liquid extraction and separated isocratically on a C 18 analytical column, with water:acetonitrile as mobile phase, run at a flow rate of 0.20 mL/min. The method was linear in the range of 0.2-50 ng/mL and demonstrated acceptable results for the precision, accuracy and stability studies. The method was successfully applied for the bioequivalence study of two tablet formulations of fluoxetine 20 mg after single oral dose administration to healthy human volunteers.

A Study of Conflict Issues Affecting Ugandan Housemaids who Migrate to Saudi Arabia and How to Mitigate them

March 10, 2026

This study aims to comprehensively analyse the complex interplay between