Formulation and Evaluation of Medicated Tolnaftate Nail Lacquer

Farsana .P; Baby Shahanas; Anu Sebastian; Ashly Merin George

Formulation and Evaluation of Medicated Tolnaftate Nail Lacquer

Farsana .P *

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Baby Shahanas

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Anu Sebastian

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Ashly Merin George

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Formulation and Evaluation of Medicated Tolnaftate Nail Lacquer

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Abstract

The present study was aimed towards the design and formulation of medicated nail lacquer of tolnaftate to control onychomycosis condition and improve the patient compliance. The present work investigated the amount of tolnaftate released from different formulations containing different concentration of ethyl cellulose and different proportions of thioglycolic acid and dimethyl sulfoxides for treatment of onychomycosis. Then these lacquers were compared for drying time, nonvolatile content, drug content, drug diffusion and antimicrobial studies. The stability test showed that the formulation were stable at 37° ± 2°C for 1 month. The results obtained from in-vitro diffusion studies showed that formulation F3 have completed drug release of 94.48% over 24 hrs. The F3 formulation had salicylic acid as keratolytic agent and 0.5ml of 1% w/v of thioglycolic acid as penetration enhancer. From diffusion studies, it was concluded that thioglycolic acid containing formulation (F2 and F3) have better penetration enhancement as compared to DMSO containing formulation. The best formulation was evaluated for antifungal sensitivity test against the Candida albicans. From the above study, it can be concluded that medicated nail lacquers proved to be a better tool.

References

8 Cites in Article

Reference Format

R Patel,Naik,Patel Suthar,A (2009). Drug Delivery across human nail.
J Sabreen,B Divyakumar,B Kiran (2008). Preungual drug delivery systems of terbinafine hydrochloride nail lacquer.
D Singh,S Roy Chowdhury,D Sharma,V Bhandari,M Singh (2013). Unknown Title.
Amrita Sawant Dessai,D Shripathi,A R Dr,Shabaraya (2014). Formulation and in vitro characterisation of nail lacquer containing fluconazole for preungual drug delivery system.
Deepa Dhiman,Sunit Kumar,Aman Mittal (2016). Formulation & evaluation of medicated nail lacquer of fluconazole to explore the difficulties in penetration of drug across nail plate and enhancement of bioavailability of antifungal drug.
M Azharuddhin,B Suresh,A Shabaraya,N Prasad (2013). Preparation and in vitro evaluation of antifungal nail lacquer.
R Manavalan,E Barish,Theodore,R Aswanivm,Venkatanarayanan (2016). Formulation and evaluation of a medicated nail lacquer for the treatment of onychomycosis.
Munmun Jaiswal,Manish Kumar,Kamla Pathak (2015). Zero order delivery of itraconazole via polymeric micelles incorporated in situ ocular gel for the management of fungal keratitis.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Farsana .P, Baby Shahanas, Anu Sebastian, Ashly Merin George. 2019. "Formulation and Evaluation of Medicated Tolnaftate Nail Lacquer". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 18 (GJMR Volume 18 Issue B5).

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GJMR Volume 18 Issue B5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-B Classification NLMC Code: QV 752

Submission ReceivedDecember 8, 2017
Peer Review Double Blind
Handling Editor
Accepted January 2, 2018
Published January 15, 2018

Version of record

v1.2

Issue date

January 4, 2019

Language

English

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Article Matrices

Total Score: 144

Country: India

Subject: Global Journal of Medical Research

Authors: Farsana .P, Baby Shahanas, Anu Sebastian, Ashly Merin George (PhD/Dr. count: 0)

View Count (all-time): 391

Total Views (Real + Logic): 1216

Total Downloads (simulated): 100

Publish Date: 2018 01, Mon

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Total Views: 1.2K

Total Downloads: 100

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