Formulation and Evaluation of Taste Masked Tablet of Sodium Feredetate: Taste Masking Approach
Iron deficiency is the most common cause of anemia worldwide. In India, 30% adult males, 45% adult females, 80% pregnant females and 60% children have iron deficiency. In our country important causes include poor dietary intake and bioavailability, increased requirement during pregnancy, lactation and growth spurt, blood loss due to menstrual disorders and hook worm infestation. So, oral supplementation with iron preparations is frequently required. Sodium Feredetate is an ant anemic agents and iron supplement drug which is widely used in iron deficiency anemia. It is having metallic taste associated with the iron. Thus, in the work under taken, attempts were made to mask the taste of drug by inclusion complex with β-cyclodextrin and fizzy chewable tablets were formulated. Experimental work: Taste masking of drug was done by inclusion complex using β-cyclodextrin in molar ratio of 1:1, 1:2, and 1:3. Inclusion complex was done by kneading method and physical mixture of drug and β-CD. Different formulations were prepared using various concentrations of sweetener, binders and disintegrate by direct compression method. The formulations were evaluated for weight variation, hardness, friability, drug content, in vitro disintegration time and in vitro dissolution studies etc. The prepared tablets were characterized by FT-IR, DSC. The taste masking studies was done by with the help of E-Tongue. Result and Discussion: Best taste masked complex was found with kneading method in 1:2 ratio. Disintegration time and release of drug of tablet prepared by using different concentration of diluent and sweetener showed thickness 16.0±0.05 mm, friability 0.13±0.01%,weight variation 1149.33±2.30 mgHardness 6.1±0.2kg/cm2,Disintegrating time 7.73±0.20 min, In vitro drug release 96.33%in 0.1 N HCl (900 ml) which were best results and within standard limits including acceptable taste. Conclusion: Among all the formulations prepared with various concentration of mannitol, formulation
