Functional Dietary Supplementation of Okara soybeans residue on Streptozotocin Induced Diabetes Mellitus in Male Wistar Rats

Nwozo Sarah O; Ikpeme Grace E; Nwawuba Stanley U

Functional Dietary Supplementation of Okara soybeans residue on Streptozotocin Induced Diabetes Mellitus in Male Wistar Rats

Nwozo Sarah O * § Mr

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Ikpeme Grace E

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Nwawuba Stanley U

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University of Ibadan

Functional Dietary Supplementation of Okara soybeans residue on Streptozotocin Induced Diabetes Mellitus in Male Wistar Rats

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Abstract

A poor dietary habit has been demonstrated to be one of the key players in the development of diabetes mellitus, and a diet rich in dietary fiber has been highlighted to be a potent candidate for the management of diabetes mellitus. Therefore, this study is aimed to validate the role of dietary supplementation of okara (soybeans residue) in streptozotocin induced diabetic male Wistar rats. The total of 28 rats between the weight of 100 to 105g, was grouped into four n=7, and this study spanned for a period of 43days. All experimentations were conducted using standard method, and our findings show that the cumulative feed intake of 15% okara diet supplementation was significantly higher p

References

49 Cites in Article

Reference Format

S Nwozo,T Modeme,S Nwawuba (2018). Evaluation of Momordica charantia, Boerhaavia diffusa and Cotreatment on Streptozotocin induced Diabetes in Male Wistar Rats.
S Nwawuba,S Nwozo,K Mohammed (2019). Dietary Management of Diabetes Mellitus with Focus on Nigeria.
S Nwozo,A Nyam,S Nwawuba,O Olukotun (2019). Hypoglycemic and Antioxidant Capacity of Curcuma Longa and Viscum Album in Alloxan Induced Diabetic Male Wistar Rats.
Ralph Hampson (2016). Health system responses to population ageing and noncommunicable diseases in AsiaV.Yiengprugsawan, J.Healy and H.Kendig (eds). World Health Organization, Regional Office for South‐East Asia, New Delhi, India, 2016. ISBN 9978 92 9022 517 1. Available from http://www.who.int/iris/handle/10665/252738.
S Nwawuba,C Monago,K Mejulu (2019). Ameliorative effect of aqueous seed extract of delonixregia on hyperglycemia, liver function and lipid profile levels in Streptozotocin induced Diabetic Male wistar rats.
Paul Chikezie,O Ojiako,K Nwufo (2015). Overview of Anti-Diabetic Medicinal Plants: The Nigerian Research Experience.
M Ismaiel,Y Hong,Cui Min (2017). Evaluation of High Fibers Okara and Soybean Bran as Functional Supplements for Mice with Experimentally Induced Type 2 Diabetes.
M Dueñas,T Hernández,S Robredo,G Lamparski,I Estrella,R Muñoz (2012). Bioactive phenolic compounds of soybean (Glycinemax cv. Merit): modifications by different microbiological fermentations.
F Nuttall (1993). Dietary fiber in the management of diabetes.
R Giacco,G Clemente,G Riccardi (2002). Dietary fibre in treatment of diabetes: myth or reality?.
I Mateos-Aparicio,C; Mateos-Peinado,P Rupérez (2010). High hydrostatic pressure improves the functionality of dietary fibre in okara by-product from soybean.
G Préstamo,P Rupérez,I Espinosa-Martos,M Villanueva,M Lasunción (2007). The effects of okara on rat growth, cecal fermentation, and serum lipids.
O Eze,J Ani,N Obasi (2014). Dietaryfibre potentials of some selected flours and their effect on blood glucose and serum cholesterol reduction.
K; Matsumoto,W Yutaka,Y Shin-Ichiro,Okara (2007). Soybean Residue, Prevents Obesity in a Diet-Induced Murine Obesity Model.
(1995). Official methods of analysis of the association of official analytical chemists, 12th edition. edited by William Horwitz. Association of official analytical chemists, p.o. box 540, Benjamin Franklin station, Washington, DC 20044, 1975 18.5 × 27cm. 1094pp. Price $40.00 (domestic); $41.00 (foreign).
Mohd Azahar,Ghanya Al-Naqeb,Mizaton Hasan,Aishah Adam (2012). Hypoglycemic effect of Octomeles sumatrana aqueous extract in streptozotocin–induced diabetic rats and its molecular mechanisms.
W Richmond (1973). Preparation and properties of a cholesterol oxidase from Nocardia specie and its application to the enzymatic assay of total cholesterol in serum.
Hara Misra,Irwin Fridovich (1972). The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase.
Asru Sinha (1972). Colorimetric assay of catalase.
E Beutler,O Duron,B Kelly (1963). Improved method for the determination of blood glutathione.
W Habig,M Pabst,W Jakoby,S-Transferases Glutathione (1974). The first enzymatic step in mercapturic acid formation.
J Rotruck,A Pope,H Ganther,A Swanson,D Hafeman,W Hoekstra (1973). Selenium: Biochemical Role as a Component of Glutathione Peroxidase.
F Sani,M Atiku,A Imam (2015). Effect of oral administration of Aqueous leaf extract of momordicacharantia (bitter melon) on serum glucose, and lipid profile in Alloxan-induced Diabetic Rats.
S Ogbonnia,J Odimegu,V Enwuru (2008). Evaluation of hypoglycemic and hypolipidemic effects of ethanolic extracts of Treculia Africana Decne and Bryopyllumpinntum Lam. and their mixture on steptozotocin (STZ) -induced diabetic rats.
Seong-Il Lim,B Lee (2010). Anti-diabetic Effect of Material Fermented Using Rice Bran and Soybean as the Main Ingredient by Bacillus sp..
S Ravipati,B Rajkumar (2011). Role of Leptin in Diabetes Mellitus.
Şebnem Gülen,Sibel Dinçer (2007). Effects of leptin on oxidative stress in healthy and Streptozotocin-induced diabetic rats.
D Sindelar,P Havel,R Seeley,C Wilkinson,S Woods,M Schwartz (1999). Low plasma leptin levels contribute to diabetic hyperphagia in rats.
F Li,Y Zhang,Z Zhong (2011). Antihyperglycemic effect of Ganoderma lucidum polysaccharides on streptozotocin-induced diabeticmice.
Fei Lu,Yang Liu,Bo Li (1349). Okara dietary fiber and hypoglycemic effect of okara foods.
S Nwozo,S Nwawuba (2019). Ameliorative Potentials of Cyperus Esculentus Oil on Type 2 Diabetes Induced by High Fat Diet and Low Dose Streptozotocin in Male Wistar Rats.
A Mooradian (2009). Dyslipidemia in type 2 diabetes mellitus.
Cicero Chang,Yenshou Lin,Arlene Bartolome,Yi-Ching Chen,Shao-Chih Chiu,Wen-Chin Yang (2013). Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds.
S Nwozo,D Adeneye,S Nwawuba (2018). Effect of Solaniummelongena fruits supplemented diet on hyperglycemia, overweight, liver function and dyslipidemia in male New Zealand rabbits fed high fat and sucrose diet.
H Elreffaei-Wael,M Eman,M Rageb,A Masoud (2014). Biological Evaluation of Okara in Rats Based on Plasma Lipid Profile and Histology.
S Nwawuba,F Okechukwu (2018). Evaluation of Liraglutide Effect on Serum Adipocytokines of Adults Male Wistar Rats with Insulin Resistance That Induced by High Fat Diet.
R Afrin,S Arumugam,V Soetikno,R Thandavarayan,V Pitchaimani,V Karuppagounder,R Sreedhar,M Harima,H Suzuki,S Miyashita,M Nomoto,K Suzuki,K Watanabe (2015). Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats.
A Omonkhua,E Adebayo,J Saliu,T Ogunwa,T Adeyelu (2014). Liver function of Streptozotocin-Induced Diabetic Rats Orally Administered Aqueous Root-Bark Extracts of Tetrapleuratetraptera (Taub).
Jamaludin Mohamed,Nazratun H.,Zariyantey H.,Budin B. (2016). Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation.
A Reid (2006). Non-alcoholic fatty liver disease.
G Shivaraj,B Prakash,S Shruthi,V Vinayak,A Avinash,N Sonal (2010). Markers of renal function tests.
S Bajaj,K Afreen (2012). Antioxidants and diabetes.
Nava Bashan,Julia Kovsan,Ilana Kachko,Hilla Ovadia,Assaf Rudich (2009). Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species.
D Gomathi,M Kalaiselvi,G Ravikumar,K Devaki,C Uma (2014). Evaluation of Antioxidants in the Kidney of Streptozotocin Induced Diabetic Rats.
Irina Chis,Marius Ungureanu,Adriana Marton,Ramona Simedrea,Adriana Muresan,Ion-Dan Postescu,Nicoleta Decea (2009). Antioxidant effects of a grape seed extract in a rat model of diabetes mellitus.
S Sheweita,S Mashaly,A Newairy,H Abdou,S Eweda (2016). Changes in Oxidative Stress and Antioxidant Enzyme Activities in Streptozotocin‐Induced Diabetes Mellitus in Rats: Role of <i>Alhagi maurorum</i> Extracts.
Ana Vital,Camila Croge,Denise Da Silva,Priscila Araújo,Mariane Gallina,Paula Matumoto-Pintro (2018). Okara residue as source of antioxidants against lipid oxidation in milk enriched with omega-3 and bioavailability of bioactive compounds after in vitro gastrointestinal digestion.
Danling Gu,Marc Arnush,Nora Sarvetnick (1997). Endocrine/Exocrine Intermediate Cells in Streptozotocin-Treated Ins-IFN-γ Transgenic Mice.
M Hori,M Michihiro,I Toshio,N Hitoshi,T Mami (2016). Possible Involvement of Pancreatic Fatty Infiltration in Pancreatic Carcinogenesis.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Nwozo O, Ikpeme E, Nwawuba U. 2019. "Functional Dietary Supplementation of Okara soybeans residue on Streptozotocin Induced Diabetes Mellitus in Male Wistar Rats". Global Journal of Medical Research, Global Journal of Medical Research - F: Diseases GJMR-F Volume 19 (GJMR Volume 19 Issue F5).

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GJMR Volume 19 Issue F5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

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Classification

GJMR-F Classification NLMC Code: WK 810

Submission ReceivedDecember 12, 2018
Peer Review Double Blind
Handling Editor
Accepted January 1, 2019
Published January 15, 2019

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v1.2

Issue date

October 17, 2019

Language

English

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Total Score: 143

Country: Nigeria

Subject: Global Journal of Medical Research

Authors: Nwozo Sarah O, Ikpeme Grace E, Nwawuba Stanley U (PhD/Dr. count: 0)

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