Genetic Factors of Diabetic Nephropatia in Patients with Type 2 Diabetes Mellitus

Ozimbay Jabborov

Genetic Factors of Diabetic Nephropatia in Patients with Type 2 Diabetes Mellitus

Ozimbay Jabborov * §

Contact

§ Tashkent Medical Academy

Genetic Factors of Diabetic Nephropatia in Patients with Type 2 Diabetes Mellitus

Article Fingerprint

ReserarchID

MRJ6NM1

Genetic Factors of Diabetic Nephropatia in Patients with Type 2 Diabetes Mellitus Banner

Key Research Insights

Synthesized scholarly intelligence & interactive research assistant

Abstract

The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well.

References

14 Cites in Article

Reference Format

M Anciferov,L Dorofeeva (2005). Avandia (rosiglitazone) is a modern insulin sensitizer for the correction of insulin resistance in type 2 diabetes mellitus // Pharmateca.
(2003). Diabetes in Children and Adolescents.
L Danilova (2010). Type 2 diabetes mellitus: modern approaches to correction.
(2007). Determining the prognosis of the development of diabetic nephropathy in patients with type 1 diabetes mellitus based on molecular genetic studies: a guide for doctors.
T Chuck (2013). Figure 12. Distribution of complication frequencies in patients with type 1 and type 2 diabetes mellitus in the "65-" and "65+" groups based on the Database of Clinical and Epidemiological Monitoring of Diabetes Mellitus in the Russian Federation..
I Yaschenko (2004). D association of the polymorphism of the angiotensin-converting enzyme gene with diabetic nephropathy in type 2 diabetes patients (residents of Chuvashia): author.
Omar Ali (2013). Genetics of type 2 diabetes.
American Association Of Diabetes Educators (2008). AADE Position Statement.
(1996). A genome-wide search for human non-insulindependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 / C.L. Hanis [et al.
Michael Brownlee,Irl Hirsch (2006). Glycemic Variability: A Hemoglobin A<sub>1c</sub>–Independent Risk Factor for Diabetic Complications.
Z Bloomgarden (2008). Diabetic nephropathy.
A Gjesing,L Kjems,M Vestmar,N Grarup,A Linneberg,C Deacon,J Holst,O Pedersen,T Hansen (2011). Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test.
Yukio Horikawa,Naohisa Oda,Nancy Cox,Xiangquan Li,Marju Orho-Melander,Manami Hara,Yoshinori Hinokio,Tom Lindner,Hirosato Mashima,Peter Schwarz,Laura Del Bosque-Plata,Yohko Horikawa,Yukie Oda,Issei Yoshiuchi,Susan Colilla,Kenneth Polonsky,Shan Wei,Patrick Concannon,Naoko Iwasaki,Jan Schulze,Leslie Baier,Clifton Bogardus,Leif Groop,Eric Boerwinkle,Craig Hanis,Graeme Bell (2000). Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
Andrzej Krolewski (1999). Genetics of diabetic nephropathy: Evidence for major and minor gene effects.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Ozimbay Jabborov. 2019. "Genetic Factors of Diabetic Nephropatia in Patients with Type 2 Diabetes Mellitus". Global Journal of Medical Research - F: Diseases GJMR-F Volume 19 (GJMR Volume 19 Issue F1).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 19 Issue F1

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Not Found

Classification

GJMR-F Classification NLMC Code: WJ 340

Submission ReceivedDecember 6, 2018
Peer Review Double Blind
Handling Editor
Accepted January 3, 2019
Published January 15, 2019

Version of record

v1.2

Issue date

February 7, 2019

Language

English

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 141

Country: Uzbekistan

Subject: Global Journal of Medical Research

Authors: Ozimbay Jabborov (PhD/Dr. count: 0)

View Count (all-time): 239

Total Views (Real + Logic): 1227

Total Downloads (simulated): 95

Publish Date: 2019 01, Tue

Monthly Totals (Real + Logic):

Month 1: 33 views
Month 2: 60 views
Month 3: 35 views
Month 4: 36 views
Month 5: 43 views
Month 6: 32 views
Month 7: 37 views
Month 8: 25 views
Month 9: 43 views
Month 10: 27 views
Month 11: 55 views
Month 12: 31 views
Month 13: 33 views
Month 14: 30 views
Month 15: 19 views
Month 16: 22 views
Month 17: 33 views
Month 18: 33 views
Month 19: 37 views
Month 20: 28 views
Month 21: 27 views
Month 22: 42 views
Month 23: 28 views
Month 24: 22 views
Month 25: 25 views
Month 26: 27 views
Month 27: 33 views
Month 28: 25 views
Month 29: 38 views
Month 30: 33 views
Month 31: 36 views
Month 32: 17 views
Month 33: 23 views
Month 34: 35 views
Month 35: 45 views
Month 36: 13 views
Month 37: 24 views
Month 38: 34 views
Month 39: 26 views
Month 40: 27 views
Month 41: 41 views
Month 42: 22 views
Month 43: 17 views
Month 44: 38 views
Month 45: 31 views
Month 46: 33 views
Month 47: 49 views
Month 48: 12 views
Month 49: 36 views
Month 50: 36 views
Month 51: 28 views
Month 52: 19 views
Month 53: 36 views
Month 54: 16 views
Month 55: 37 views
Month 56: 14 views
Month 57: 50 views
Month 58: 20 views
Month 59: 20 views
Month 60: 20 views
Month 61: 45 views
Month 62: 39 views
Month 63: 37 views
Month 64: 48 views
Month 65: 30 views
Month 66: 23 views
Month 67: 23 views
Month 68: 17 views
Month 69: 35 views
Month 70: 27 views
Month 71: 11 views
Month 72: 32 views
Month 73: 36 views
Month 74: 31 views
Month 75: 28 views
Month 76: 21 views
Month 77: 23 views
Month 78: 23 views
Month 79: 40 views
Month 80: 38 views
Month 81: 42 views
Month 82: 26 views
Month 83: 47 views
Month 84: 24 views
Month 85: 46 views
Month 86: 49 views
Month 87: 40 views
Month 88: 32 views
Month 89: 33 views
Month 90: 33 views
Month 91: 64 views
Month 92: 37 views
Month 93: 38 views

Total Views: 1.2K

Total Downloads: 95

All Trends