Glutathione S-Transferase Activity of Three Erythrocyte Genotypes of Human Participants Treated with Pyrimethamine/Sulphadoxine and Quinine

Glutathione S-Transferase Activity of Three Erythrocyte Genotypes of Human Participants Treated with Pyrimethamine/Sulphadoxine and Quinine

Chikezie

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Paul Chidoka Chikezie

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University of Port Harcourt

Glutathione S-Transferase Activity of Three Erythrocyte Genotypes of Human Participants Treated with Pyrimethamine/Sulphadoxine and Quinine

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Abstract

erythrocytes with 1-chloro-2, 4-dinitrobenzene (CDNB) caused quantitative conjugation of reduced glutathione (GSH) to produce S-(2, 4-dinitrophenyl) glutathione, which formed the bases for the measurement of Ery-GST activity using a spectrophotometer. Blood samples were drawn from treated non-malarious and malarious participants at time intervals of 0, 3, 6 and 18 h and measured for Ery-GST activity. The control values of Ery-GST activity of non-malarious and malarious participants were within the ranges of 3.27 ± 0.13 -12.50 ± 1.58 IU/gHb and 2.75 ± 0.16 -12.21 ± 1.20 IU/gHb respectively.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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How to Cite This Article

Chikezie. 2014. \u201cGlutathione S-Transferase Activity of Three Erythrocyte Genotypes of Human Participants Treated with Pyrimethamine/Sulphadoxine and Quinine\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B6): .

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GJMR Volume 14 Issue B6
Pg. 5- 12

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

1-chloro-2 4- dinitrobenzene (CDNB)erythrocytes glutathione S-transferase activity pyrimethamine/sulphadoxine Quinine

Submission ReceivedDecember 11, 2013
Peer Review Double Blind
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Accepted December 31, 2013
Published January 15, 2014

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Total Score: 101

Country: Nigeria

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Paul Chidoka Chikezie (PhD/Dr. count: 0)

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