Hepatoprotective Effect of Merlot Grape Pomace Extract Against Acetaminophen Induced Damage in Mouse

1
Claudriana Locatelli
Claudriana Locatelli
2
Viviane Cassaneli Spader
Viviane Cassaneli Spader
3
Diego de Carvalho
Diego de Carvalho
4
Conrado de Oliveira Gamba
Conrado de Oliveira Gamba
5
Natan Veiga
Natan Veiga
6
Karine Luz
Karine Luz

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This study investigated the benefits of Merlot grape pomace extract (EBUM) in experimental acetaminophen-induced intoxication. Swiss mice received the respective treatments for 7 days: Control (saline), Silymarin (100 mg/Kg), EBUM: 100 mg/Kg and 500 mg/Kg. On the seventh day, the acetaminophen control, Silymarin and EBUM received a single dose of acetaminophen 500 mg/kg. After 24 hours, the mice were sacrificed, the blood and liver were collected for analysis of serum transaminases (ALT and AST), bilirubin, hepatic markers of oxidative stress and histopathological analysis. EBUM was able to prevent acetaminopheninduced hepatic necrosis with a significant reduction (p

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No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Claudriana Locatelli. 2026. \u201cHepatoprotective Effect of Merlot Grape Pomace Extract Against Acetaminophen Induced Damage in Mouse\u201d. Global Journal of Human-Social Science - H: Interdisciplinary GJHSS-H Volume 23 (GJHSS Volume 23 Issue H9): .

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Hepatoprotective effects of natural compounds on liver damage and research insights.
Journal Specifications

Crossref Journal DOI 10.17406/GJHSS

Print ISSN 0975-587X

e-ISSN 2249-460X

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GJHSS-H Classification: LCC Code: QV 766
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v1.2

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January 27, 2024

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English

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This study investigated the benefits of Merlot grape pomace extract (EBUM) in experimental acetaminophen-induced intoxication. Swiss mice received the respective treatments for 7 days: Control (saline), Silymarin (100 mg/Kg), EBUM: 100 mg/Kg and 500 mg/Kg. On the seventh day, the acetaminophen control, Silymarin and EBUM received a single dose of acetaminophen 500 mg/kg. After 24 hours, the mice were sacrificed, the blood and liver were collected for analysis of serum transaminases (ALT and AST), bilirubin, hepatic markers of oxidative stress and histopathological analysis. EBUM was able to prevent acetaminopheninduced hepatic necrosis with a significant reduction (p

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Hepatoprotective Effect of Merlot Grape Pomace Extract Against Acetaminophen Induced Damage in Mouse

Claudriana Locatelli
Claudriana Locatelli
Viviane Cassaneli Spader
Viviane Cassaneli Spader
Diego de Carvalho
Diego de Carvalho
Conrado de Oliveira Gamba
Conrado de Oliveira Gamba
Natan Veiga
Natan Veiga
Karine Luz
Karine Luz

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