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ReserarchID
PDDTM3382C
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
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The histopathological view of liver, intestines and kidney of bacterial infected rabbits, fed with 100mg/ml saponin extracted from Phyllanthus niruri over a period of seven days was carried out to determine the effect of the plant extract on these organs after treatment. Saponin was administered as strawberry suspension at a dose of 10mg per day (divided into four doses) to ten rabbits, nine of which were fed with food contaminated with 0.5mL bacterial suspension obtained by McFarland standardization (10% Barium sulfate) after starvation for 6hrs . Multiple foci of tubular necrosis and haemorrhages in the kidney, marked hyperplasia of the mucosal layer of the small intestine, and a mild periportal lymphocytic cellular infiltration of the liver of the treated rabbits were observed. Plasma urea, uric acid, creatinine and blood glucose levels increased significantly (p < 0.05) in the treated rabbits.
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