Hormonal and Mineral Changes in Early Stages of Chronic Kidney Diseases

Awad Magbri

Hormonal and Mineral Changes in Early Stages of Chronic Kidney Diseases

Awad Magbri * §

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§ Dialysis Access Center of Pittsburgh

Hormonal and Mineral Changes in Early Stages of Chronic Kidney Diseases

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Abstract

This study evaluates divalent ion abnormalities (DIA) and the hormonal changes throughout the spectrum of early CKD stages (1-4) as defined by K/DOQI. A total of 96 patients (48.96% males, mean age 62±13 yrs) with CKD 1 to 4, were prospectively evaluated and followed-up. There were (20, 27, 32, and 17 patients in CKD-1, 2, 3, and 4 respectively). The diagnosis was confirmed by renal biopsy, Table -1.Mean serum creatinine (62±32 umol/L). Plasma levels of calcium, phosphorus, calcitriol (CTRL), and parathyroid hormone (PTH) were evaluated among the groups. A 24-hour urinary creatinine, calcium (Uca), phosphorus (Up), creatinine clearance and fractional excretion of calcium (FeCa), and phosphorus (FeP) were also compared. PTH was measured using the standard IRMA test (normal values 10-50 pg/dl), and calcitriol was measured by RIA test (normal values are 74.5 -169 pmol/l). The exclusion criteria are nephrolithiasis, hypercalcemia, proteinuria >3g/24 hrs, previous renal transplant, and therapy with steroids or anticonvulsants (Phenytoin).

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Awad Magbri. 2016. "Hormonal and Mineral Changes in Early Stages of Chronic Kidney Diseases". Global Journal of Medical Research - F: Diseases GJMR-F Volume 16 (GJMR Volume 16 Issue F2).

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GJMR Volume 16 Issue F2

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-F Classification NLMC Code: WJ 378

WJ 300

Submission ReceivedDecember 15, 2015
Peer Review Double Blind
Handling Editor
Accepted January 2, 2016
Published January 15, 2016

Version of record

v1.2

Issue date

April 30, 2016

Language

English

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Total Score: 176

Country: United States

Subject: Global Journal of Medical Research

Authors: Awad Magbri, Hervas JG, Eussera El-Magbri, Mariam El-Magbri, Taha El-Magbri, Llach F (PhD/Dr. count: 0)

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