Human Infection Studies and the SARS-CoV-2 Pandemic

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Jörg Tremmel
Jörg Tremmel

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GJMR Volume 23 Issue F3

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Introduction-What could humanity have done better in fighting the SARS-CoV-2 pandemic? From a financial and scientific point of view, it has done many things right, but a crucial ethical question has remained rather unexamined. In this paper, I argue that controlled human infection studies (HIS) would have been ethically justifiable and the right way forward in developing a vaccine against Covid-19. The phase 2/3 trials of the vaccines from AstraZeneca, Pfizer/Biontech and Moderna took between 112 and 196 days. Human challenge trials would have taken much less time, about 30 days. In retrospect, these three vaccines could have been launched 82 to 166 days earlier than they actually were. If this had happened, hundreds of thousands of deaths and millions of hospitalisations worldwide could have been avoided due to the cumulative effect. In terms of preparatory measures for the next pandemic, the ethical discussion on HIS is of utmost relevance for the well-being of future generations.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

Jörg Tremmel. 2026. \u201cHuman Infection Studies and the SARS-CoV-2 Pandemic\u201d. Global Journal of Medical Research - F: Diseases GJMR-F Volume 23 (GJMR Volume 23 Issue F3): .

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Global Journals - Academic Research.
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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-F Classification: DDC Code: 614.5 LCC Code: RA644.S17
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March 27, 2023

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English

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Introduction-What could humanity have done better in fighting the SARS-CoV-2 pandemic? From a financial and scientific point of view, it has done many things right, but a crucial ethical question has remained rather unexamined. In this paper, I argue that controlled human infection studies (HIS) would have been ethically justifiable and the right way forward in developing a vaccine against Covid-19. The phase 2/3 trials of the vaccines from AstraZeneca, Pfizer/Biontech and Moderna took between 112 and 196 days. Human challenge trials would have taken much less time, about 30 days. In retrospect, these three vaccines could have been launched 82 to 166 days earlier than they actually were. If this had happened, hundreds of thousands of deaths and millions of hospitalisations worldwide could have been avoided due to the cumulative effect. In terms of preparatory measures for the next pandemic, the ethical discussion on HIS is of utmost relevance for the well-being of future generations.

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Human Infection Studies and the SARS-CoV-2 Pandemic

Jörg Tremmel
Jörg Tremmel

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