I-Catenin Role and Expression in Oral Squamous Cell Carcinoma

Khaled Zaid

I-Catenin Role and Expression in Oral Squamous Cell Carcinoma

Khaled Zaid * §

Contact

Damascus University

I-Catenin Role and Expression in Oral Squamous Cell Carcinoma

Article Fingerprint

ReserarchID

MREASOG

I-Catenin Role and Expression in Oral Squamous Cell Carcinoma Banner

AI TAKEAWAY

Abstract

This study aimed to reveal the role and altered immunohistochemical expression of αcatenin in oral squamous cell carcinoma progression in its three histopathological differentiations. Immunohistochemical method was used to stain 81 biopsy taken from 81 patients and 15 control sample from normal oral mucosa. α-catenin was detected with homogenous strong staining in 56.6%, 40%, 15% of well, moderately, poorly differentiated squamous cell carcinomas, respectively with p

References

30 Cites in Article

Reference Format

Khaled Zaid (2014). Immunohistochemical Assessment of E-cadherin and β-catenin in the Histological Differentiations of Oral Squamous Cell Carcinoma.
K Willert,K Jones (2006). Wnt signaling: is the party in the nucleus?.
Brian Robinson,Kenneth Moberg (2011). Cell–Cell Junctions: α-Catenin and E-Cadherin Help Fence In Yap1.
M Lee (2011). JNK regulates binding of alphacatenin to adherens junctions and cell-cell adhesion.
A Stocker,A Chenn (2009). Focal reduction of alphaE-catenin causes premature differentiation and reduction of beta-catenin signaling during cortical development.
S Hansen (2013). alphaE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors.
Lisa Mohamet,Kate Hawkins,Christopher Ward (2011). Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of Tumorigenesis.
K Abe,M Takeichi (2008). EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.
Noboru Ishiyama,Nobutoshi Tanaka,Kentaro Abe,Yoo Yang,Yazan Abbas,Masataka Umitsu,Bhushan Nagar,Stephanie Bueler,John Rubinstein,Masatoshi Takeichi,Mitsuhiko Ikura (2013). An Autoinhibited Structure of α-Catenin and Its Implications for Vinculin Recruitment to Adherens Junctions.
K Tachibana (2000). Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins.
A Kobielak,H Pasolli,E Fuchs (2004). Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables.
Jessica Maiers (2013). The role of alpha-catenin and ZO-1 in coupling tight junctions to adherens junctions.
A Abu Taha,H Schnittler (2014). Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions.
J Benjamin (2010). AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cellcell adhesion.
D Rimm (1995). Alpha 1(E)-catenin is an actinbinding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.
E Carico (2012). Expression of E-cadherin and alpha-catenin in T1 N0 laryngeal cancer.
Shun-Roku Takauji,Manabu Watanabe,Rina Uyama,Takayuki Nakagawa,Nozomi Miyajima,Manabu Mochizuki,Ryohei Nishimura,Sumio Sugano,Nobuo Sasaki (2007). Expression and Subcellular Localization of E-Cadherin, .ALPHA.-Catenin, and .BETA.-Catenin in 8 Feline Mammary Tumor Cell Lines.
Hajime Kuroda,Jun-Ichi Tamaru,Ikuya Takeuchi,Kiyoshi Ohnisi,Goi Sakamoto,Akiko Adachi,Kou Kaneko,Shinji Itoyama (2006). Expression of E-cadherin, α-catenin, and β-catenin in tubulolobular carcinoma of the breast.
H Tuhkanen (2004). Marked allelic imbalance on chromosome 5q31 does not explain alpha-catenin expression in epithelial ovarian cancer.
T Jiang (2012). Expressions of E-cadherin and alpha-catenin in benign, malignant and metastatic prostate tumors.
Adam Elzagheid,Abdelbaset Buhmeida,Eija Korkeila,Yrjö Collan,Kari Syrjänen,Seppo Pyrhönen (2008). Up-regulation of a-catenin is associated with increased lymph node involvement in colorectal cancer.
Masamichi Imajo,Koichi Miyatake,Akira Iimura,Atsumu Miyamoto,Eisuke Nishida (2012). A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β‐catenin signalling.
S Landis (1999). Cancer statistics.
Akhilesh Krishna,R Singh,Shraddha Singh,Pratima Verma,U Pal,Sunita Tiwari (2014). Demographic Risk Factors, Affected Anatomical Sites and Clinicopathological Profile for Oral Squamous Cell Carcinoma in a North Indian Population.
M Quadri (2015). Oral squamous cell carcinoma and associated risk factors in jazan, saudi arabia: a hospital based case control study.
M Zigler,A Dobroff,M Bar-Eli (2010). Cell adhesion: implication in tumor progression.
E Carico (2001). E-cadherin and alpha-catenin expression during tumor progression of cervical carcinoma.
N Tanaka,T Odajima,K Ogi,T Ikeda,M Satoh (2003). Expression of E-cadherin, α-catenin, and β-catenin in the process of lymph node metastasis in oral squamous cell carcinoma.
T Sakaki (1999). Correlation of E-cadherin and alpha-catenin expression with differentiation of oral squamous cell carcinoma.
R Zeng Prognostic significance of betacatenin expression in patients with esophageal.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Khaled Zaid. 2016. "I-Catenin Role and Expression in Oral Squamous Cell Carcinoma". Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 15 (GJMR Volume 15 Issue C5).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 15 Issue C5

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Not Found

Classification

GJMR-C Classification NLMC Code: WP 460

Submission ReceivedDecember 10, 2014
Peer Review Double Blind
Handling Editor
Accepted January 3, 2015
Published January 15, 2015

Version of record

v1.2

Issue date

January 6, 2016

Language

English

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 144

Country: Unknown

Subject: Global Journal of Medical Research

Authors: Khaled Zaid, Mansour Chantiri, Mhd Thabit Murad , Mostafa Almoustafa Alhosni (PhD/Dr. count: 0)

View Count (all-time): 330

Total Views (Real + Logic): 1596

Total Downloads (simulated): 94

Publish Date: 2015 01, Thu

Monthly Totals (Real + Logic):

Month 1: 55 views
Month 2: 50 views
Month 3: 30 views
Month 4: 40 views
Month 5: 27 views
Month 6: 32 views
Month 7: 44 views
Month 8: 30 views
Month 9: 46 views
Month 10: 50 views
Month 11: 53 views
Month 12: 14 views
Month 13: 37 views
Month 14: 20 views
Month 15: 22 views
Month 16: 29 views
Month 17: 37 views
Month 18: 22 views
Month 19: 26 views
Month 20: 31 views
Month 21: 29 views
Month 22: 28 views
Month 23: 23 views
Month 24: 27 views
Month 25: 34 views
Month 26: 27 views
Month 27: 30 views
Month 28: 26 views
Month 29: 16 views
Month 30: 18 views
Month 31: 27 views
Month 32: 29 views
Month 33: 30 views
Month 34: 47 views
Month 35: 34 views
Month 36: 23 views
Month 37: 47 views
Month 38: 38 views
Month 39: 42 views
Month 40: 31 views
Month 41: 25 views
Month 42: 46 views
Month 43: 22 views
Month 44: 17 views
Month 45: 18 views
Month 46: 38 views
Month 47: 24 views
Month 48: 36 views
Month 49: 36 views
Month 50: 32 views
Month 51: 36 views
Month 52: 22 views
Month 53: 17 views
Month 54: 29 views
Month 55: 33 views
Month 56: 28 views
Month 57: 31 views
Month 58: 33 views
Month 59: 20 views
Month 60: 33 views
Month 61: 41 views
Month 62: 31 views
Month 63: 39 views
Month 64: 44 views
Month 65: 26 views
Month 66: 21 views
Month 67: 42 views
Month 68: 42 views
Month 69: 36 views
Month 70: 36 views
Month 71: 15 views
Month 72: 41 views
Month 73: 34 views
Month 74: 20 views
Month 75: 30 views
Month 76: 40 views
Month 77: 27 views
Month 78: 30 views
Month 79: 21 views
Month 80: 37 views
Month 81: 22 views
Month 82: 35 views
Month 83: 15 views
Month 84: 33 views
Month 85: 37 views
Month 86: 39 views
Month 87: 38 views
Month 88: 26 views
Month 89: 49 views
Month 90: 28 views
Month 91: 18 views
Month 92: 38 views
Month 93: 31 views
Month 94: 27 views
Month 95: 40 views
Month 96: 40 views
Month 97: 28 views
Month 98: 32 views
Month 99: 36 views
Month 100: 21 views
Month 101: 28 views
Month 102: 31 views
Month 103: 33 views
Month 104: 45 views
Month 105: 24 views
Month 106: 34 views
Month 107: 49 views
Month 108: 28 views
Month 109: 37 views
Month 110: 36 views
Month 111: 39 views
Month 112: 39 views
Month 113: 31 views
Month 114: 29 views
Month 115: 25 views
Month 116: 46 views
Month 117: 29 views
Month 118: 53 views
Month 119: 48 views
Month 120: 24 views
Month 121: 31 views
Month 122: 73 views
Month 123: 55 views
Month 124: 39 views
Month 125: 65 views
Month 126: 32 views
Month 127: 28 views
Month 128: 37 views
Month 129: 22 views
Month 130: 27 views
Month 131: 24 views
Month 132: 32 views
Month 133: 37 views
Month 134: 38 views
Month 135: 31 views
Month 136: 25 views
Month 137: 39 views
Month 138: 61 views
Month 139: 34 views
Month 140: 53 views
Month 141: 30 views

Total Views: 1.6K

Total Downloads: 94

All Trends