Identification of the Role of LuxS in the Regulation of Motility & the Expression of the Flagellar Structural & Functional Regulators in Vibrio cholerae

Chandradipa Ghosh; Dr. Smritikana Biswas; Prithwiraj Mukherjee

Identification of the Role of LuxS in the Regulation of Motility & the Expression of the Flagellar Structural & Functional Regulators in Vibrio cholerae

Chandradipa Ghosh * §

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Dr. Smritikana Biswas

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Prithwiraj Mukherjee

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§ Vidyasagar University Medinipur-West, West Bengal, I...

Identification of the Role of LuxS in the Regulation of Motility & the Expression of the Flagellar Structural & Functional Regulators in Vibrio cholerae

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Abstract

In Vibrio cholerae motility has an important role in virulence. Beside this flrA, flrB and flrC regulate the expression of both flagellar structure and function in Vibrio cholerae. Quorum sensing autoinducer molecules regulate the expression of EPS in Vibrio cholerae O139 Bengal strain MO10. The present study was conducted to investigate whether luxS gene (responsible for the synthesis of quorum sensing autoinducer molecule 2 i.e, AI-2) regulates motility as well as expression of both structural and functional regulatory genes flrA, flrB and flrC. In the peresent study we found that mutation in luxS gene caused reduction in motility and expression of flra was significantly decreased in the luxS mutant strain of the Vibrio cholerae O139 Bengal strain MO10 lac -. However expression of flrB and flrC remained unaltered by luxs gene. So luxS gene may regulate motility through the upregulation of flrA in Vibrio cholerae O139 Bengal strain MO10.

References

23 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Chandradipa Ghosh, Dr. Biswas, Prithwiraj Mukherjee. 1970. "Identification of the Role of LuxS in the Regulation of Motility & the Expression of the Flagellar Structural & Functional Regulators in Vibrio cholerae". Global Journal of Medical Research, Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 12 (GJMR Volume 12 Issue K5).

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GJMR Volume 12 Issue K5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

motility Vibrio cholerae O139 Bengal strain MO10 lac-Δ -galactosidase assay Δ flaAluxS Δ luxS

Classification

GJMR-K Classification NLMC Code: WC 262

WW 410

QW 51

QU 21

Submission ReceivedMarch 8, 2012
Peer Review Double Blind
Handling Editor
Accepted April 7, 2012
Published April 21, 2012

Version of record

v1.2

Language

English

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Article Matrices

Total Score: 149

Country: India

Subject: Global Journal of Medical Research

Authors: Dr. Smritikana Biswas, Prithwiraj Mukherjee, Shyamalendu Kar, Chandradipa Ghosh (PhD/Dr. count: 1)

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Publish Date: 2012 04, Sat

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Total Views: 6K

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