Incidental Finding of Panhypogammaglobulinaemia in Pregnancy-an Extremely Rare Condition

Crishan V. Haran

Incidental Finding of Panhypogammaglobulinaemia in Pregnancy-an Extremely Rare Condition

Crishan V. Haran *

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Incidental Finding of Panhypogammaglobulinaemia in Pregnancy-an Extremely Rare Condition

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Abstract

A 22 year old lady, G2P0 presented at a 311 weeks of gestation with an abnormal group and antibody test found incidentally during routine 28 week blood testing. She reported no past medical history apart from medication controlled gestational diabetes and denied any family history of autoimmune diseases. She was subsequently diagnosed with panhypogam-maglobulinemia. After consultation with an immune-ologist, a number of blood investigations were undertaken, all of which were negative, except for an MRI which showed a possible small thymoma. All fetal ultrasounds were unremarkable. Given the importance of transplacental immunoglobulin (Ig) transfer in the third trimester and the concern of serious infection during pregnancy she has was commenced on intravenous immunoglobulin (IVIg). After a loading dose of IVIg (0.6mg/kg) and a subsequent dose (0.4mg/kg) her Ig level was 10. She was administered a third dose and it was decided that her Ig levels be monitored weekly and IVIg only administered should her levels drop below 7. Since her Ig levels dropped to 6.9g/L at 37 5 weeks of gestation, she received another dose (0.4mg/kg). She underwent a normal delivery at 391 weeks and was diagnosed with a thymoma postnatally.

References

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Crishan V. Haran. 2014. "Incidental Finding of Panhypogammaglobulinaemia in Pregnancy-an Extremely Rare Condition". Global Journal of Medical Research - E: Gynecology & Obstetrics GJMR-E Volume 14 (GJMR Volume 14 Issue E2).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-E Classification NLMC Code: WP 660

Submission ReceivedDecember 12, 2013
Peer Review Double Blind
Handling Editor
Accepted January 3, 2014
Published January 15, 2014

Version of record

v1.2

Issue date

July 20, 2014

Language

English

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Total Score: 177

Country: Australia

Subject: Global Journal of Medical Research

Authors: Crishan V. Haran, Dr. Sabaratnam Ganeshananthan (PhD/Dr. count: 1)

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Publish Date: 2014 01, Wed

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