Increased TNF serum levels are related to highly aggressive behavior in male Swiss Webster mice

1
Fernanda da Silva Oliveira
Fernanda da Silva Oliveira
2
Cynthia Machado Cascabulho
Cynthia Machado Cascabulho
3
Kelly Cristina Demarque
Kelly Cristina Demarque
4
JanaAna Alves Rangel
JanaAna Alves Rangel
5
Frederico Villas Boas Rodrigues
Frederico Villas Boas Rodrigues
6
Wanderson Silva Batista1
Wanderson Silva Batista1
7
Lucas dos Santos Gameiro
Lucas dos Santos Gameiro
8
Gabriel Melo de Oliveira
Gabriel Melo de Oliveira
1 Instituto Oswaldo Cruz - FundaAAo Oswaldo Cruz/RJ

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Since the 1960s, mouse behavior has been systematically studied in the laboratory environment; however, there is still no consensus regarding the causes of aggression in laboratory animals. The involvement of the immune response in aggressive animal behavior has not been well elucidated. Different studies have found that the levels of interferon alpha (IFN-α), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α) are elevated in depressogenic/anxiogenic models. The aim of this study is to assess the correlations of serum cytokine (TNF, IL-6 and IL-10) levels with patterns of aggressive behavior (PBA). Our results suggest that mice exhibiting anxiety-like and highly aggressive behaviors have increased TNF serum levels and slightly decreased IL-10 levels. Additionally, a direct correlation was observed between high PBA scores and increased levels of TNF.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

Fernanda da Silva Oliveira. 2014. \u201cIncreased TNF serum levels are related to highly aggressive behavior in male Swiss Webster mice\u201d. Global Journal of Medical Research - G: Veterinary Science & Medicine GJMR-G Volume 13 (GJMR Volume 13 Issue G2): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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v1.2

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January 29, 2014

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English

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Since the 1960s, mouse behavior has been systematically studied in the laboratory environment; however, there is still no consensus regarding the causes of aggression in laboratory animals. The involvement of the immune response in aggressive animal behavior has not been well elucidated. Different studies have found that the levels of interferon alpha (IFN-α), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α) are elevated in depressogenic/anxiogenic models. The aim of this study is to assess the correlations of serum cytokine (TNF, IL-6 and IL-10) levels with patterns of aggressive behavior (PBA). Our results suggest that mice exhibiting anxiety-like and highly aggressive behaviors have increased TNF serum levels and slightly decreased IL-10 levels. Additionally, a direct correlation was observed between high PBA scores and increased levels of TNF.

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Increased TNF serum levels are related to highly aggressive behavior in male Swiss Webster mice

Fernanda da Silva Oliveira
Fernanda da Silva Oliveira
Cynthia Machado Cascabulho
Cynthia Machado Cascabulho
Kelly Cristina Demarque
Kelly Cristina Demarque
JanaAna Alves Rangel
JanaAna Alves Rangel
Frederico Villas Boas Rodrigues
Frederico Villas Boas Rodrigues
Wanderson Silva Batista1
Wanderson Silva Batista1
Lucas dos Santos Gameiro
Lucas dos Santos Gameiro
Gabriel Melo de Oliveira
Gabriel Melo de Oliveira

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