Influence of Anti Diabetic Therapy on Plasma Lipid Profile and Its Relation to Erythrocyte Membrane Lipid Levels in Type 2 Diabetic Subjects

Influence of Anti Diabetic Therapy on Plasma Lipid Profile and Its Relation to Erythrocyte Membrane Lipid Levels in Type 2 Diabetic Subjects

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LFZ4K

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Influence of Anti Diabetic Therapy on Plasma Lipid Profile and Its Relation to Erythrocyte Membrane Lipid Levels in Type 2 Diabetic Subjects

Dr. Basavaraj.S.Aski BLDE University SRI B.M.Patil Medical College BIJAPUR.

B.B.Devarnavadagi

G. Rudrappa

R.T.Kashinath

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Abstract

The diabetes induced dyslipidemia may lead to an alteration in RBC membrane cholesterol/phospholipids ratio in diabetic subjects resulting in an alteration in RBC membrane properties. It has been observed in our laboratory that diabetes induced dyslipidemia causes a change in RBC membrane lipid composition in type 2 diabetic subjects. The effect of various oral anti diabetic drugs and or Insulin therapy on diabetes induced RBC membrane lipid alteration is not established. Hence the present work was undertaken to study the influence of anti diabetic drugs and or Insulin on RBC membrane lipid composition in type 2 diabetic subjects. Blood samples from randomly selected type 2 diabetic subjects were collected after obtaining written consent. The plasma lipids as well as RBC membrane lipids were estimated. The study group include normal subjects (group-1), control diabetics diabetic subjects (group-2), diabetic subjects receiving oral drugs (group-3), diabetic subjects receiving insulin (group-4) and diabetic subjects receiving both oral drugs and insulin (group-5). The study suggest an increase in plasma lipid levels with a parallel raise in RBC membrane lipid composition in diabetic subjects and hypoglycemic drugs -insulin combined therapy regime may help to control the diabetic dyslipidemia induced erythrocyte membrane lipid alterations.

Influence of Anti Diabetic Therapy on Plasma Lipid Profile and Its Relation to Erythrocyte Membrane Lipid Levels in Type 2 Diabetic Subjects

Authors

Dr. Basavaraj.S.Aski BLDE University SRI B.M.Patil Medical College BIJAPUR.

B.B.Devarnavadagi

G. Rudrappa

R.T.Kashinath

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Dr. Basavaraj.S.Aski. 1970. “. Unknown Journal GJMR Volume 12 (GJMR Volume 12 Issue 11): .

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GJMR Volume 12 Issue 11
Pg. 9- 16

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Submission Received February 14, 2012
Accepted March 4, 2012
Published March 15, 2012

Keywords

anti diabetic drugs plasma Lipids RBC membrane lipids

Article Matrices

Total Score: 109

Country: India

Subject: Uncategorized

Authors: Dr. Basavaraj.S.Aski, B.B.Devarnavadagi, G. Rudrappa, R.T.Kashinath (PhD/Dr. count: 1)

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Publish Date: 1970 01, Thu

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