Intermittent Preexcitation and Electrotonic Modulation of Repolarization as a Cause of Macroscopic T Wave Alternans

Adrian Baranchuk

Intermittent Preexcitation and Electrotonic Modulation of Repolarization as a Cause of Macroscopic T Wave Alternans

Adrian Baranchuk * §

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§ Queens University

Intermittent Preexcitation and Electrotonic Modulation of Repolarization as a Cause of Macroscopic T Wave Alternans

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Abstract

Alterations in ventricular depolarization are recognized to lead to inverted T-waves which manifest once the ventricular activation returns to normal. This phenomenon referred to as ‘T-wave memory’ or ‘electrotonic modulation’ may be caused by several clinical conditions producing a shift in ventricular depolarization. Currently, T wave alternans (TWA), either macroscopic or microscopic refers to the beat to beat alteration in the repolarization heterogeneity that repeats with every other beat without changes in the QRS complex. We present the case of a 43-year old man with symptomatic intermittent pre-excitation who underwent 24-hour Holter monitoring revealing TWA secondary to electrotonic modulation. It is assumed that this phenomenon does not carry any prognostic significance.

References

5 Cites in Article

Reference Format

Mauricio Rosenbaum,Horacio Blanco,Marcelo Elizari,Julio Lázzari,Jorge Davidenko (1982). Electrotonic modulation of the T wave and cardiac memory.
A Armoundas,G Tomaselli,H Esperer (2002). Pathophysiological basis and clinical application of T-wave alternans.
S Kalbfleisch,J Sousa,R El-Atassi,H Calkins,J Langberg,F Morady (1991). Repolarization abnormalities after catheter ablation of accessory atrioventricular connections with radio frequency current.
C Patel,J Burke,H Patel,P Gupta,P Kowey,C Antzelevitch,G Yan (2009). Cellular basis of the T wave. A century of controversy.
M Franz,K Bargheer,W Rafflenbeul,A Haverich,P Lichtlen (1987). Monophasic action potential mapping in human subjects with normal electrocardiograms: direct evidence for the genesis of the T wave..

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Adrian Baranchuk. 2013. "Intermittent Preexcitation and Electrotonic Modulation of Repolarization as a Cause of Macroscopic T Wave Alternans". Global Journal of Medical Research - D: Radiology, Diagnostic GJMR-D Volume 13 (GJMR Volume 13 Issue D2).

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GJMR Volume 13 Issue D2

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

cardiac memory electrotonic modulation intermittent preexcitation T wave alternans

Classification

GJMR-D Classification NLMC Code: QT 34

Submission ReceivedDecember 12, 2012
Peer Review Double Blind
Handling Editor
Accepted January 5, 2013
Published January 15, 2013

Version of record

v1.2

Issue date

August 10, 2013

Language

English

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Article Matrices

Total Score: 173

Country: Canada

Subject: Global Journal of Medical Research

Authors: Riyaz Somani, Jane Caldwell, Adrian Baranchuk (PhD/Dr. count: 0)

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