Intranasal Nystatin Therapy in Patients with Chronic Illness Associated with Mold and Mycotoxins

Joseph H. Brewer; Dennis Hooper; Shalini Muralidhar

Intranasal Nystatin Therapy in Patients with Chronic Illness Associated with Mold and Mycotoxins

Joseph H. Brewer * §

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Dennis Hooper

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Shalini Muralidhar

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University of Missouri - Kansas City

Intranasal Nystatin Therapy in Patients with Chronic Illness Associated with Mold and Mycotoxins

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Abstract

We have previously reported that patients with chronic illness frequently had a history of prior exposure to water damaged buildings (WDB) and mold. These patients were found to have elevated levels of mycotoxins in the urine. We postulated that the mycotoxin producing molds colonize the sinuses of these patients and lead to chronic symptoms. In a recent observational analysis of patients treated with intranasal antifungal agents, either amphotericin B (AMB) or itraconazole (ITR), we showed that 94% of these patients improved clinically (AMB group). We also found that the urine mycotoxin levels decreased substantially in patients that improved on therapy. However, AMB was associated with local (nasal irritation) adverse effects (AE) in 34% of the cases, which resulted in discontinuation of therapy. The present study expands these treatment observations in which patients intolerant to AMB were treated with intranasal nystatin (NYS). We found very promising improvements with this agent as well. No local (nasal) AE were seen with NYS.

References

8 Cites in Article

Reference Format

Jack Thrasher,Sandra Crawley (2009). The biocontaminants and complexity of damp indoor spaces: more than what meets the eyes.
J Brewer,J Thrasher,D Straus,R Madison,D Hooper (2013). Detection of mycotoxins in patients with chronic fatigue syndrome.
Joseph Brewer,Jack Thrasher,Dennis Hooper (2014). Chronic Illness Associated with Mold and Mycotoxins: Is Naso-Sinus Fungal Biofilm the Culprit?.
J Brewer,D Hooper,S Muralidhar (2015). Intranasal antifungal therapy in chronic illness patients associated with mold and mycotoxins: An observational analysis.
Karen Oakley,Caroline Moore,David Denning (1999). Comparison of In Vitro Activity of Liposomal Nystatin against <i>Aspergillus</i> Species with Those of Nystatin, Amphotericin B (AB) Deoxycholate, AB Colloidal Dispersion, Liposomal AB, AB Lipid Complex, and Itraconazole.
(2013). Mycostatin Oral Suspension (Ready-mixed). Summary of product characteristics.
Emer Reeves,Thomas Murphy,Paul Daly,Kevin Kavanagh (2004). Amphotericin B enhances the synthesis and release of the immunosuppressive agent gliotoxin from the pulmonary pathogen Aspergillus fumigatus.
Eilidh Mowat,John Butcher,Sue Lang,Craig Williams,Gordon Ramage (2007). Development of a simple model for studying the effects of antifungal agents on multicellular communities of Aspergillus fumigatus.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Joseph H. Brewer, Dennis Hooper, Shalini Muralidhar. 2015. "Intranasal Nystatin Therapy in Patients with Chronic Illness Associated with Mold and Mycotoxins". Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 15 (GJMR Volume 15 Issue K5).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-K Classification NLMC Code: QW 630.5.M9

Submission ReceivedFebruary 7, 2015
Peer Review Double Blind
Handling Editor
Accepted March 2, 2015
Published March 15, 2015

Version of record

v1.2

Issue date

December 29, 2015

Language

English

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Article Matrices

Total Score: 173

Country: United States

Subject: Global Journal of Medical Research

Authors: Joseph H. Brewer, Dennis Hooper, Shalini Muralidhar (PhD/Dr. count: 0)

View Count (all-time): 368

Total Views (Real + Logic): 1174

Total Downloads (simulated): 50

Publish Date: 2015 03, Sun

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