Neural Networks and Rules-based Systems used to Find Rational and Scientific Correlations between being Here and Now with Afterlife Conditions
Neural Networks and Rules-based Systems used to Find Rational and
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The present experiment was designed to develop colon specific drug delivery system of ketorolac tromethiamine (KT) for treatment of various colonic disorders. Matrix tablets were prepared by direct compression technique utilizing combination of guar gum with various types of biodegradable/pH dependent/hydrophilic retarders. Tablets evaluated for quality control tests and in-vitro liberation studies (24h). In vivo roentogenographic studies and stability studies performed for optimized formulation. KT containing combination of guar gum with HPMCP (Hypromellose Phthalate) 55S released negligible amount in 1.2 pH and 7.4 phosphate buffers and 70% released in 6.8 pH (simulated colonic fluid) whereas 95% of KT released in 6.8 pH buffer (ratcaecal content). In-vivo roentogenographic studies of optimized formulation (F10) showed location of the tablet at 30 mins, 3 h and 8 h was in stomach, caecum and ascending colon respectively. FT-IR & DSC reveals that no interaction between drug and used excipients.
Kalyani Chithaluru. 2013. \u201cKetorolac Tromethiamine Tablets Targeting to Colon through Microbial Degradation and pH Dependence: Development and Roentogenographic Studies\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue B5): .
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
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Total Score: 102
Country: India
Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine
Authors: Kalyani Chithaluru , Rama Rao Tadikonda (PhD/Dr. count: 0)
View Count (all-time): 125
Total Views (Real + Logic): 4749
Total Downloads (simulated): 2401
Publish Date: 2013 10, Thu
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The present experiment was designed to develop colon specific drug delivery system of ketorolac tromethiamine (KT) for treatment of various colonic disorders. Matrix tablets were prepared by direct compression technique utilizing combination of guar gum with various types of biodegradable/pH dependent/hydrophilic retarders. Tablets evaluated for quality control tests and in-vitro liberation studies (24h). In vivo roentogenographic studies and stability studies performed for optimized formulation. KT containing combination of guar gum with HPMCP (Hypromellose Phthalate) 55S released negligible amount in 1.2 pH and 7.4 phosphate buffers and 70% released in 6.8 pH (simulated colonic fluid) whereas 95% of KT released in 6.8 pH buffer (ratcaecal content). In-vivo roentogenographic studies of optimized formulation (F10) showed location of the tablet at 30 mins, 3 h and 8 h was in stomach, caecum and ascending colon respectively. FT-IR & DSC reveals that no interaction between drug and used excipients.
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