L-lysine Neuro-Dynamic Optimal Control

1
Dr. Tatiana Ilkova
Dr. Tatiana Ilkova Ph.D.
2
Dr. Mitko Petrov
Dr. Mitko Petrov
1 Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences

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GJMR Volume 11 Issue 4

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In this paper Neuro-dynamic programming (NDP) is proposed as an alternative to alleviate the “curse of dimensionality” of the Dynamic programming (DP) for optimal control of a fed-batch fermentation process in the L-lysine production. The most effective and cheapest method for the Llysine biosynthesis (in biological active form) is the microbiological method via a direct fermentation. In this paper an optimization method of the L-lysine production from strain Brevibacterium flavum 22LD is used and that is NDP. The results show that the quality of L-lysine enhances at the end of the process. The proposed method is particularly simple to implement and can be applied for on-line optimization.

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No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

Dr. Tatiana Ilkova. 1970. \u201cL-lysine Neuro-Dynamic Optimal Control\u201d. Unknown Journal GJMR Volume 11 (GJMR Volume 11 Issue 4): .

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December 23, 2011

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In this paper Neuro-dynamic programming (NDP) is proposed as an alternative to alleviate the “curse of dimensionality” of the Dynamic programming (DP) for optimal control of a fed-batch fermentation process in the L-lysine production. The most effective and cheapest method for the Llysine biosynthesis (in biological active form) is the microbiological method via a direct fermentation. In this paper an optimization method of the L-lysine production from strain Brevibacterium flavum 22LD is used and that is NDP. The results show that the quality of L-lysine enhances at the end of the process. The proposed method is particularly simple to implement and can be applied for on-line optimization.

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L-lysine Neuro-Dynamic Optimal Control

Dr. Tatiana Ilkova
Dr. Tatiana Ilkova Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences
Dr. Mitko Petrov
Dr. Mitko Petrov

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