Lipid Profile and Urinary Protein a Creatinine Ratio Changes in Pre-Eclampsia Cases in and Around Chitradurga
Pre-eclampsia is defined by the new onset of elevated blood pressure and proteinuria after 20 weeks of gestation.According to current studies dyslipidemia, particularly the rise in serum triglycerides is a contributing factor in pre-eclampsia. There is a positive correlation between serum triglycerides and systolic blood pressure in pre-eclampsia cases .Urinary protein- creatinine ratio has been used to evaluate proteinuria in pre-eclampsia, this parameter is sensitive and predictive as well.The presence of proteinuria is seen as a possible indication of many complications in pregnancy, from urinary tract infection to chronic renal disease and it remains central to the diagnosis of pre-eclampsia in a hypertensive pregnancy. It has both diagnostic and prognostic implications . Extensive changes occur in the renal system in pre-eclampsia. As a part of the end organ pathology pre-eclamptic glomeruli undergo structural changes with pronounced endothelial vacuolization and hypertrophy of the cytoplasmic organelles, first defined as glomerular endotheliosis. A case control comparative study was done with preeclampsia and normal pregnant women .both for out door patient and indoor patients of Basaveshwara Medical College Hospital & RC, Chitradurga according to the criteria. Study group will be followed up every 4 weeks in first 28 weeks of gestation. Blood samples and 24 hr/random urine samples will be collected for biochemical evaluation of lipid parameters and urinary protein and urinary creatinine . In this study, It was found that there were significant increases in levels of Triglycerides & LDL-Cholesterol (p < 0.001),Slight increases in Total cholesterol levels(p < 0.001) and significant decreases inHDL-Cholesterol levels(p < 0.001) in cases of preeclampsia in comparison to normal pregnant women Urinary creatinine levels in cases of preeclampsia showed decreased levels (p<0.001) and Protein /creatinine ratio in urine showed significant increases (p<0.001) as compared
