Low-Level Laser for Prevention of Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Acute Leukemia, HC/UFMG 2012-2013

1
Natalice Sousa de Oliveira
Natalice Sousa de Oliveira
2
Clia Regina Moreira Lanza
Clia Regina Moreira Lanza
3
Rachel Aparecida Ferreira Fernandes
Rachel Aparecida Ferreira Fernandes
4
Denise Vieira Travassos
Denise Vieira Travassos
5
Jos Carlos Serufo
Jos Carlos Serufo
1 Departamento de ClAnica Mdica

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Oral mucositis (OM) is the non-hematological toxicity with the highest prevalence and morbidity in anticancer treatment. This study evaluated the use of low-level laser for the prevention of chemotherapy-induced OM by comparing 101 cycles with prophylactic irradiation using a gallium aluminum arsenide (GaAlAs) laser diode (λ=660 nm; P=40 mW, dose of 4 J/cm²) and 121 cycles with no irradiation. The conditions associated with oral health, chemotherapy cycles, neutropenia patterns, infectious complications and nutritional status were evaluated. OM occurred in 41.9% of the cycles. The probability of developing OM in the final cycles (7 to 10) was 7.34 times higher than in the initial cycles (1 to 6); 4.19 times higher in febrile neutropenia than in physiological neutropenia; 2.08 times higher when a therapeutic antimicrobial drug was used; and 2.12 times higher when gingivitis was present.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

Natalice Sousa de Oliveira. 2014. \u201cLow-Level Laser for Prevention of Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Acute Leukemia, HC/UFMG 2012-2013\u201d. Global Journal of Medical Research - J: Dentistry & Otolaryngology GJMR-J Volume 14 (GJMR Volume 14 Issue J2): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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June 3, 2014

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English

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Oral mucositis (OM) is the non-hematological toxicity with the highest prevalence and morbidity in anticancer treatment. This study evaluated the use of low-level laser for the prevention of chemotherapy-induced OM by comparing 101 cycles with prophylactic irradiation using a gallium aluminum arsenide (GaAlAs) laser diode (λ=660 nm; P=40 mW, dose of 4 J/cm²) and 121 cycles with no irradiation. The conditions associated with oral health, chemotherapy cycles, neutropenia patterns, infectious complications and nutritional status were evaluated. OM occurred in 41.9% of the cycles. The probability of developing OM in the final cycles (7 to 10) was 7.34 times higher than in the initial cycles (1 to 6); 4.19 times higher in febrile neutropenia than in physiological neutropenia; 2.08 times higher when a therapeutic antimicrobial drug was used; and 2.12 times higher when gingivitis was present.

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Low-Level Laser for Prevention of Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Acute Leukemia, HC/UFMG 2012-2013

Natalice Sousa de Oliveira
Natalice Sousa de Oliveira Departamento de ClAnica Mdica
Clia Regina Moreira Lanza
Clia Regina Moreira Lanza
Rachel Aparecida Ferreira Fernandes
Rachel Aparecida Ferreira Fernandes
Denise Vieira Travassos
Denise Vieira Travassos
Jos Carlos Serufo
Jos Carlos Serufo

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