Epidemiological, Clinical, Paraclinical, Therapeutic, Evolutionary, and Prognostic Aspects of Intraparenchymal Hematomas in the Medical Neurocritical Care Unit of the Ibrahima Pierre NDIAYE Neuroscience Clinic: A Study of 72 Cases

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Epidemiological, Clinical, Paraclinical, Therapeutic, Evolutionary, and Prognostic Aspects of Intraparenchymal Hematomas in the Medical Neurocritical Care Unit of the Ibrahima Pierre NDIAYE Neuroscience Clinic: A Study of 72 Cases

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Epidemiological, Clinical, Paraclinical, Therapeutic, Evolutionary, and Prognostic Aspects of Intraparenchymal Hematomas in the Medical Neurocritical Care Unit of the Ibrahima Pierre NDIAYE Neuroscience Clinic: A Study of 72 Cases Banner

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Introduction: The objective of our study was to evaluate, in a population of Togolese P eople Living With HIV(PLWHIV), the agreement between three scores derived from the general population namely the Framingham score, the Systematic Coronary Risk Evaluation (SCORE), the evaluation of the cardiovascular risk (CVR) according to the World Health Organization (WHO) and the CVR evaluation equation derived from the Data collection on Adverse effects of anti-HIV Drugs (D.A.D). Methods: We conducted a descriptive and analytical cross-sectional study including 212 HIV-infected patients recruited from the day hospital of the Infectious Diseases Department of the Sylvanus Olympio University Hospital. The level of agreement between the different scores was estimated using the Pearson correlation test and the Cohen Kappa coefficient. Results: The median age of the participants (68.9% female) was 50.2 years (IQR: 44.8-56.0). Eighty-seven point sevenpercent of the participants were on highly active antiretroviral therapy, 87.1% of whom were on a combinationof two nucleoside inhibitors and one non-nucleoside inhibitor. The most represented cardiovascular risk factors were abdominal obesity (56.1%), HDL hypocholesterolemia (52.4%) and hypertension (44.8%). The median cardiovascular risk was 6.3% (IQR: 3.9% -11.2%), 0.0% (IQR: 0.0% -1.0%), 4.0% (IQR: 3.0% -8.0%), 3.0% (IQR: 1.95-5.01), based on the Framingham, SCORE, WHO and D.A.D scores respectively. There was a strong positive and statistically significant correlation between CVR scores based on the general population and scores obtained using the D.A.D algorithm: Framingham and D.A.D (r = 0.802; p??0.001); SCORE and D.A.D (r = 0.652; p??0.001); WHO and D.A.D (r = 0.577; p??0.001). The level of agreement in classifying low, moderate and high risk patients between the Framingham score and the D.A.D score was 71.2% (?Β§ = 0.19 CI: 0.09-0.29; p??0.001). The SCORE risk and the WHO score showed respectively an agreement level of 89.6% (?Β§ = 0.276 CI: 0.123-0.428; p??0.001) and 83.9% (?Β§ = 0.21 CI: 0.06-0.35; p ??0.001) with the D.A.D score. Conclusion: The overall CVR estimated by the different CVR estimation scores allowed us to highlight a low prevalence of PLWHIV with high CVR. The WHO clinical CVR estimation scale could be a low cost alternative to evaluate CVR in resource-limited countries such as Togo.

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Epidemiological, Clinical, Paraclinical, Therapeutic, Evolutionary, and Prognostic Aspects of Intraparenchymal Hematomas in the Medical Neurocritical Care Unit of the Ibrahima Pierre NDIAYE Neuroscience Clinic: A Study of 72 Cases

Serigne Abdou Fall
Serigne Abdou Fall Centre Hospitalier National Universitaire de Fann
Mbaye THIOUB
Mbaye THIOUB Centre Hospitalier National Universitaire de Fan
Rose Carla MBINA MBINA
Rose Carla MBINA MBINA <p>Centre Hospitalier National Universitaire de Fann</p>
Adjaratou Dieynabou SOW
Adjaratou Dieynabou SOW <p>Centre Hospitalier National Universitaire de Fann</p>
Ndiaga Matar GAYE
Ndiaga Matar GAYE <p>Centre Hospitalier National Universitaire de Fann</p>
Marième Soda DIOP
Marième Soda DIOP <p>Centre Hospitalier National Universitaire de Fann</p>
Anna Mbodji BASSE
Anna Mbodji BASSE <p>Centre Hospitalier National Universitaire de Fann</p>
Lala Bouna SECK
Lala Bouna SECK <p>Centre Hospitalier National Universitaire de Fann</p>
Moustapha NDIAYE
Moustapha NDIAYE <p>Centre Hospitalier National Universitaire de Fann</p>