Mass Spectrometric Identification of Catabolic Pathways in the Selected Amphibian Skin Peptides With the Saliva and the Major Salivary Protease, Kallikrein

1
Xiaole Chen
Xiaole Chen
2
He Wang
He Wang
3
Lei Wang
Lei Wang
4
Mei Zhou
Mei Zhou
5
Tianbao Chen
Tianbao Chen
6
Chris Shaw
Chris Shaw
1 Fujian Medical University

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Mass Spectrometric Identification of Catabolic Pathways in the Selected Amphibian Skin Peptides With the Saliva and the Major Salivary Protease, Kallikrein Banner
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As nature has selected amphibian skin defensive peptides for inter-species delivery through the oral route in the recipient, structural stabilisation modifications may have occurred to facilitate this and such information would be most useful and could potentially provide new insights to the design of orally-active and selectively-targeted peptide therapeutics. The purposes of this study were to study catabolic pathways in saliva for selected but commonly occurring bioactive peptide types belonging to the protease inhibitor (PI) and bradykinin-related peptide (BRP) families, namely pLR (LVRGCWTKS-YPPKPCFVR), HV-BBI (SVIGCWTKSIPPRPC FVK) and I-11-R (IRRPPGFSPLR), and to extend this study by determining catabolic pathways with kallikrein -the major salivary protease. These data will aid in the establishment of a database of peptide stabilities that may be useful in the design of future orally-delivered peptide therapeutics.

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No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

Xiaole Chen. 2016. \u201cMass Spectrometric Identification of Catabolic Pathways in the Selected Amphibian Skin Peptides With the Saliva and the Major Salivary Protease, Kallikrein\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 16 (GJMR Volume 16 Issue B2): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification: NLMC Code: QU 68, QY 125
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August 6, 2016

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English

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As nature has selected amphibian skin defensive peptides for inter-species delivery through the oral route in the recipient, structural stabilisation modifications may have occurred to facilitate this and such information would be most useful and could potentially provide new insights to the design of orally-active and selectively-targeted peptide therapeutics. The purposes of this study were to study catabolic pathways in saliva for selected but commonly occurring bioactive peptide types belonging to the protease inhibitor (PI) and bradykinin-related peptide (BRP) families, namely pLR (LVRGCWTKS-YPPKPCFVR), HV-BBI (SVIGCWTKSIPPRPC FVK) and I-11-R (IRRPPGFSPLR), and to extend this study by determining catabolic pathways with kallikrein -the major salivary protease. These data will aid in the establishment of a database of peptide stabilities that may be useful in the design of future orally-delivered peptide therapeutics.

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Mass Spectrometric Identification of Catabolic Pathways in the Selected Amphibian Skin Peptides With the Saliva and the Major Salivary Protease, Kallikrein

Xiaole Chen
Xiaole Chen Fujian Medical University
He Wang
He Wang
Lei Wang
Lei Wang
Mei Zhou
Mei Zhou
Tianbao Chen
Tianbao Chen
Chris Shaw
Chris Shaw

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