Mass Spectrometric Identification of Catabolic Pathways in the Selected Amphibian Skin Peptides With the Saliva and the Major Salivary Protease, Kallikrein

Mass Spectrometric Identification of Catabolic Pathways in the Selected Amphibian Skin Peptides With the Saliva and the Major Salivary Protease, Kallikrein

Xiaole Chen

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He Wang

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Lei Wang

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Mei Zhou

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Tianbao Chen

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Chris Shaw

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Fujian Medical University

Mass Spectrometric Identification of Catabolic Pathways in the Selected Amphibian Skin Peptides With the Saliva and the Major Salivary Protease, Kallikrein

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Abstract

As nature has selected amphibian skin defensive peptides for inter-species delivery through the oral route in the recipient, structural stabilisation modifications may have occurred to facilitate this and such information would be most useful and could potentially provide new insights to the design of orally-active and selectively-targeted peptide therapeutics. The purposes of this study were to study catabolic pathways in saliva for selected but commonly occurring bioactive peptide types belonging to the protease inhibitor (PI) and bradykinin-related peptide (BRP) families, namely pLR (LVRGCWTKS-YPPKPCFVR), HV-BBI (SVIGCWTKSIPPRPC FVK) and I-11-R (IRRPPGFSPLR), and to extend this study by determining catabolic pathways with kallikrein -the major salivary protease. These data will aid in the establishment of a database of peptide stabilities that may be useful in the design of future orally-delivered peptide therapeutics.

References

22 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Xiaole Chen. 2016. \u201cMass Spectrometric Identification of Catabolic Pathways in the Selected Amphibian Skin Peptides With the Saliva and the Major Salivary Protease, Kallikrein\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 16 (GJMR Volume 16 Issue B2).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification NLMC Code: QU 68

QY 125

Submission ReceivedDecember 16, 2015
Peer Review Double Blind
Handling Editor
Accepted January 2, 2016
Published January 15, 2016

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v1.2

Issue date

August 6, 2016

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Article Matrices

Total Score: 136

Country: China

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Xiaole Chen, He Wang, Lei Wang, Mei Zhou, Tianbao Chen, Chris Shaw (PhD/Dr. count: 0)

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Publish Date: 2016 08, Sat

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Total Views: 3960

Total Downloads: 1991

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