Metal Catalyzed Synthesis and Antimicrobial Studies of some New Amido Derivatives of Non-Linear Polycyclic Diazaphenothiazinone

1
Evelyn Uloma Godwin–Nwakwasi
Evelyn Uloma Godwin–Nwakwasi
2
Uchechukwu Chris. Okoro
Uchechukwu Chris. Okoro
3
Mercy Amarachukwu Ezeokonkwo
Mercy Amarachukwu Ezeokonkwo
4
Ifeoma Chinyere Ugwu
Ifeoma Chinyere Ugwu
5
Fidelia Ngozi Ibeanu
Fidelia Ngozi Ibeanu
1 Gregory University Uturu

Send Message

To: Author

GJSFR Volume 19 Issue B2

Article Fingerprint

ReserarchID

Z25S4

Metal Catalyzed Synthesis and Antimicrobial Studies of some New Amido Derivatives of Non-Linear Polycyclic Diazaphenothiazinone Banner
  • English
  • Afrikaans
  • Albanian
  • Amharic
  • Arabic
  • Armenian
  • Azerbaijani
  • Basque
  • Belarusian
  • Bengali
  • Bosnian
  • Bulgarian
  • Catalan
  • Cebuano
  • Chichewa
  • Chinese (Simplified)
  • Chinese (Traditional)
  • Corsican
  • Croatian
  • Czech
  • Danish
  • Dutch
  • Esperanto
  • Estonian
  • Filipino
  • Finnish
  • French
  • Frisian
  • Galician
  • Georgian
  • German
  • Greek
  • Gujarati
  • Haitian Creole
  • Hausa
  • Hawaiian
  • Hebrew
  • Hindi
  • Hmong
  • Hungarian
  • Icelandic
  • Igbo
  • Indonesian
  • Irish
  • Italian
  • Japanese
  • Javanese
  • Kannada
  • Kazakh
  • Khmer
  • Korean
  • Kurdish (Kurmanji)
  • Kyrgyz
  • Lao
  • Latin
  • Latvian
  • Lithuanian
  • Luxembourgish
  • Macedonian
  • Malagasy
  • Malay
  • Malayalam
  • Maltese
  • Maori
  • Marathi
  • Mongolian
  • Myanmar (Burmese)
  • Nepali
  • Norwegian
  • Pashto
  • Persian
  • Polish
  • Portuguese
  • Punjabi
  • Romanian
  • Russian
  • Samoan
  • Scots Gaelic
  • Serbian
  • Sesotho
  • Shona
  • Sindhi
  • Sinhala
  • Slovak
  • Slovenian
  • Somali
  • Spanish
  • Sundanese
  • Swahili
  • Swedish
  • Tajik
  • Tamil
  • Telugu
  • Thai
  • Turkish
  • Ukrainian
  • Urdu
  • Uzbek
  • Vietnamese
  • Welsh
  • Xhosa
  • Yiddish
  • Yoruba
  • Zulu

The synthesis of novel non-linear polycyclic diazaphenothiazine and its amido derivatives via Buchwald -Hartwig reaction protocol is reported. By reacting 2-amino-5bromopyrazine-3[4H]-thione and 2, 3-dichloro-1, 4-naphthoquinone in the presence of anhydrous sodium carbonate, 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a] phenothiazin-5-one was obtained. The arylation of 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a]pheno-thiazin-5-one with some amides under palladium catalysis gave the amido derivatives in good yield. The stability of these cyclic quinoneimine systems, which has been attributed to ionic resonance effect, is noted. Structural assignments were based on UV, IR and NMR spectra as well as elemental analysis. These compounds showed significant antimicrobial activity against E. coli, Staphylococcus spp, Bacillus spp. and Pseudomonas aeruginosa at varying concentrations.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

Evelyn Uloma Godwin–Nwakwasi. 2019. \u201cMetal Catalyzed Synthesis and Antimicrobial Studies of some New Amido Derivatives of Non-Linear Polycyclic Diazaphenothiazinone\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 19 (GJSFR Volume 19 Issue B2): .

Download Citation

Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords
Classification
GJSFR-B Classification: FOR Code: 030399p
Version of record

v1.2

Issue date

June 25, 2019

Language

English

Experiance in AR

The methods for personal identification and authentication are no exception.

Read in 3D

The methods for personal identification and authentication are no exception.

Article Matrices
Total Views: 2695
Total Downloads: 1287
2026 Trends
Research Identity (RIN)
Related Research

Published Article

The synthesis of novel non-linear polycyclic diazaphenothiazine and its amido derivatives via Buchwald -Hartwig reaction protocol is reported. By reacting 2-amino-5bromopyrazine-3[4H]-thione and 2, 3-dichloro-1, 4-naphthoquinone in the presence of anhydrous sodium carbonate, 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a] phenothiazin-5-one was obtained. The arylation of 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a]pheno-thiazin-5-one with some amides under palladium catalysis gave the amido derivatives in good yield. The stability of these cyclic quinoneimine systems, which has been attributed to ionic resonance effect, is noted. Structural assignments were based on UV, IR and NMR spectra as well as elemental analysis. These compounds showed significant antimicrobial activity against E. coli, Staphylococcus spp, Bacillus spp. and Pseudomonas aeruginosa at varying concentrations.

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]
×

This Page is Under Development

We are currently updating this article page for a better experience.

Request Access

Please fill out the form below to request access to this research paper. Your request will be reviewed by the editorial or author team.
X

Quote and Order Details

Contact Person

Invoice Address

Notes or Comments

This is the heading

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

High-quality academic research articles on global topics and journals.

Metal Catalyzed Synthesis and Antimicrobial Studies of some New Amido Derivatives of Non-Linear Polycyclic Diazaphenothiazinone

Evelyn Uloma Godwin–Nwakwasi
Evelyn Uloma Godwin–Nwakwasi Gregory University Uturu
Uchechukwu Chris. Okoro
Uchechukwu Chris. Okoro
Mercy Amarachukwu Ezeokonkwo
Mercy Amarachukwu Ezeokonkwo
Ifeoma Chinyere Ugwu
Ifeoma Chinyere Ugwu
Fidelia Ngozi Ibeanu
Fidelia Ngozi Ibeanu

Research Journals