Neural Networks and Rules-based Systems used to Find Rational and Scientific Correlations between being Here and Now with Afterlife Conditions
Neural Networks and Rules-based Systems used to Find Rational and
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The synthesis of novel non-linear polycyclic diazaphenothiazine and its amido derivatives via Buchwald -Hartwig reaction protocol is reported. By reacting 2-amino-5bromopyrazine-3[4H]-thione and 2, 3-dichloro-1, 4-naphthoquinone in the presence of anhydrous sodium carbonate, 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a] phenothiazin-5-one was obtained. The arylation of 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a]pheno-thiazin-5-one with some amides under palladium catalysis gave the amido derivatives in good yield. The stability of these cyclic quinoneimine systems, which has been attributed to ionic resonance effect, is noted. Structural assignments were based on UV, IR and NMR spectra as well as elemental analysis. These compounds showed significant antimicrobial activity against E. coli, Staphylococcus spp, Bacillus spp. and Pseudomonas aeruginosa at varying concentrations.
Evelyn Uloma Godwin–Nwakwasi. 2019. \u201cMetal Catalyzed Synthesis and Antimicrobial Studies of some New Amido Derivatives of Non-Linear Polycyclic Diazaphenothiazinone\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 19 (GJSFR Volume 19 Issue B2): .
Crossref Journal DOI 10.17406/GJSFR
Print ISSN 0975-5896
e-ISSN 2249-4626
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Total Score: 105
Country: Nigeria
Subject: Global Journal of Science Frontier Research - B: Chemistry
Authors: Evelyn Uloma Godwin–Nwakwasi, Uchechukwu Chris. Okoro, Mercy Amarachukwu Ezeokonkwo, Ifeoma Chinyere Ugwu, Fidelia Ngozi Ibeanu (PhD/Dr. count: 0)
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Publish Date: 2019 06, Tue
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The synthesis of novel non-linear polycyclic diazaphenothiazine and its amido derivatives via Buchwald -Hartwig reaction protocol is reported. By reacting 2-amino-5bromopyrazine-3[4H]-thione and 2, 3-dichloro-1, 4-naphthoquinone in the presence of anhydrous sodium carbonate, 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a] phenothiazin-5-one was obtained. The arylation of 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a]pheno-thiazin-5-one with some amides under palladium catalysis gave the amido derivatives in good yield. The stability of these cyclic quinoneimine systems, which has been attributed to ionic resonance effect, is noted. Structural assignments were based on UV, IR and NMR spectra as well as elemental analysis. These compounds showed significant antimicrobial activity against E. coli, Staphylococcus spp, Bacillus spp. and Pseudomonas aeruginosa at varying concentrations.
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