Metal Catalyzed Synthesis and Antimicrobial Studies of some New Amido Derivatives of Non-Linear Polycyclic Diazaphenothiazinone

Metal Catalyzed Synthesis and Antimicrobial Studies of some New Amido Derivatives of Non-Linear Polycyclic Diazaphenothiazinone

Evelyn Uloma Godwin–Nwakwasi

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Uchechukwu Chris. Okoro

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Mercy Amarachukwu Ezeokonkwo

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Ifeoma Chinyere Ugwu

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Fidelia Ngozi Ibeanu

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Gregory University Uturu

Metal Catalyzed Synthesis and Antimicrobial Studies of some New Amido Derivatives of Non-Linear Polycyclic Diazaphenothiazinone

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Abstract

The synthesis of novel non-linear polycyclic diazaphenothiazine and its amido derivatives via Buchwald -Hartwig reaction protocol is reported. By reacting 2-amino-5bromopyrazine-3[4H]-thione and 2, 3-dichloro-1, 4-naphthoquinone in the presence of anhydrous sodium carbonate, 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a] phenothiazin-5-one was obtained. The arylation of 9-bromo-6-chloro-8, 11-daiza-5H-benzo[a]pheno-thiazin-5-one with some amides under palladium catalysis gave the amido derivatives in good yield. The stability of these cyclic quinoneimine systems, which has been attributed to ionic resonance effect, is noted. Structural assignments were based on UV, IR and NMR spectra as well as elemental analysis. These compounds showed significant antimicrobial activity against E. coli, Staphylococcus spp, Bacillus spp. and Pseudomonas aeruginosa at varying concentrations.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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How to Cite This Article

Evelyn Uloma Godwin–Nwakwasi. 2019. \u201cMetal Catalyzed Synthesis and Antimicrobial Studies of some New Amido Derivatives of Non-Linear Polycyclic Diazaphenothiazinone\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 19 (GJSFR Volume 19 Issue B2).

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GJSFR Volume 19 Issue B2

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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GJSFR-B Classification FOR Code: 030399p

Submission ReceivedDecember 5, 2018
Peer Review Double Blind
Handling Editor
Accepted December 27, 2018
Published January 7, 2019

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June 25, 2019

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Article Matrices

Total Score: 105

Country: Nigeria

Subject: Global Journal of Science Frontier Research - B: Chemistry

Authors: Evelyn Uloma Godwin–Nwakwasi, Uchechukwu Chris. Okoro, Mercy Amarachukwu Ezeokonkwo, Ifeoma Chinyere Ugwu, Fidelia Ngozi Ibeanu (PhD/Dr. count: 0)

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