Neural Networks and Rules-based Systems used to Find Rational and Scientific Correlations between being Here and Now with Afterlife Conditions
Neural Networks and Rules-based Systems used to Find Rational and
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Infection of SARS-COV2 and its variants causes wide range morbidity and mortality in recent years. Identification of epitope-based mechanism of viral infection with progressive fatality and antiviral immunotherapy are two major goals to address population-bias immune response. We selected peptides from SARS-COV2 Spike (6VXX_A), Delta (B.1.617.2), Omicron (B.1.1.529) proteins. These peptides contain epitopes which are identified as low rank good fit immunogenic as recognized more by HLA-DRB1*15:01, than HLA-DRB1*07:01 and HLA-DRB1*03:01. We also found the selected epitopes specifically form interactive complex with mucosa-associated invariant T cell. The Molecular Docking and Molecular Dynamics experiments demonstrated amino acid sequence-specific interaction between close atoms from epitopes and MAIT-TCR. We used virus unrelated microbial peptide antigen85 as control.
Subhajit Dasgupta. 2026. \u201cMucosal-Invariant T Cell Receptor Recognizes HLA-DRB1 Selected SARS-Epitopes\u201d. Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 23 (GJMR Volume 23 Issue K2): .
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
The methods for personal identification and authentication are no exception.
Total Score: 133
Country: United States
Subject: Global Journal of Medical Research - K: Interdisciplinary
Authors: Subhajit Dasgupta, Shaoni Dasgupta,, Mausumi Bandyopadhyay (PhD/Dr. count: 0)
View Count (all-time): 107
Total Views (Real + Logic): 1179
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Publish Date: 2026 01, Fri
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Infection of SARS-COV2 and its variants causes wide range morbidity and mortality in recent years. Identification of epitope-based mechanism of viral infection with progressive fatality and antiviral immunotherapy are two major goals to address population-bias immune response. We selected peptides from SARS-COV2 Spike (6VXX_A), Delta (B.1.617.2), Omicron (B.1.1.529) proteins. These peptides contain epitopes which are identified as low rank good fit immunogenic as recognized more by HLA-DRB1*15:01, than HLA-DRB1*07:01 and HLA-DRB1*03:01. We also found the selected epitopes specifically form interactive complex with mucosa-associated invariant T cell. The Molecular Docking and Molecular Dynamics experiments demonstrated amino acid sequence-specific interaction between close atoms from epitopes and MAIT-TCR. We used virus unrelated microbial peptide antigen85 as control.
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