Mucosal-Invariant T Cell Receptor Recognizes HLA-DRB1 Selected SARS-Epitopes

1
Subhajit Dasgupta
Subhajit Dasgupta
2
Shaoni Dasgupta
Shaoni Dasgupta
3
Mausumi Bandyopadhyay
Mausumi Bandyopadhyay

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Infection of SARS-COV2 and its variants causes wide range morbidity and mortality in recent years. Identification of epitope-based mechanism of viral infection with progressive fatality and antiviral immunotherapy are two major goals to address population-bias immune response. We selected peptides from SARS-COV2 Spike (6VXX_A), Delta (B.1.617.2), Omicron (B.1.1.529) proteins. These peptides contain epitopes which are identified as low rank good fit immunogenic as recognized more by HLA-DRB1*15:01, than HLA-DRB1*07:01 and HLA-DRB1*03:01. We also found the selected epitopes specifically form interactive complex with mucosa-associated invariant T cell. The Molecular Docking and Molecular Dynamics experiments demonstrated amino acid sequence-specific interaction between close atoms from epitopes and MAIT-TCR. We used virus unrelated microbial peptide antigen85 as control.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

Subhajit Dasgupta. 2026. \u201cMucosal-Invariant T Cell Receptor Recognizes HLA-DRB1 Selected SARS-Epitopes\u201d. Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 23 (GJMR Volume 23 Issue K2): .

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Enhanced immune response to SARS-CoV-2 in mucosal tissues. Study identifies key epitopes recognizing HLA-DRB1.
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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-K Classification: NLM: QW 504
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v1.2

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April 21, 2023

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English

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Infection of SARS-COV2 and its variants causes wide range morbidity and mortality in recent years. Identification of epitope-based mechanism of viral infection with progressive fatality and antiviral immunotherapy are two major goals to address population-bias immune response. We selected peptides from SARS-COV2 Spike (6VXX_A), Delta (B.1.617.2), Omicron (B.1.1.529) proteins. These peptides contain epitopes which are identified as low rank good fit immunogenic as recognized more by HLA-DRB1*15:01, than HLA-DRB1*07:01 and HLA-DRB1*03:01. We also found the selected epitopes specifically form interactive complex with mucosa-associated invariant T cell. The Molecular Docking and Molecular Dynamics experiments demonstrated amino acid sequence-specific interaction between close atoms from epitopes and MAIT-TCR. We used virus unrelated microbial peptide antigen85 as control.

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Mucosal-Invariant T Cell Receptor Recognizes HLA-DRB1 Selected SARS-Epitopes

Subhajit Dasgupta
Subhajit Dasgupta
Shaoni Dasgupta
Shaoni Dasgupta
Mausumi Bandyopadhyay
Mausumi Bandyopadhyay

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