Neuropathic Pain: Basic to Advanced Neuropathic Pain

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Santosh Nagare
Santosh Nagare

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As we know that pain is the most common reason for which a patient takes medicine. Pain is not a single entity but may be classified as nociceptive pain, inflammatory pain, and neuropathic pain. Nociceptive pain such pain can be healed or cured by using NSAIDs and other analgesics. Neuropathic pain is caused by the direct lesion on the neuron or damage or dysfunction of peripheral or central neurons. Minor neuropathic can cured automatically because peripheral nervous systems neuron surrounded by Schwann cell which promotes the healing of neurons but CNS neurons don’t have Schwan cell they are covered with oligodendrocytes which don’t have self healing property so pain mediated through CNS are generally chronic. Even the smallest stimulation results in spontaneous intense pain after that it gets transformed into chronic pain syndrome which is difficult to treat.In chronic pain syndrome, plastic changes occur in nociceptive neurons which cant be reversed by pharmacological treatment. In this review, we have discussed the core pathophysiology of neuropathic pain and advances in it to date.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

Santosh Nagare. 2021. \u201cNeuropathic Pain: Basic to Advanced Neuropathic Pain\u201d. Global Journal of Medical Research - A: Neurology & Nervous System GJMR-A Volume 21 (GJMR Volume 21 Issue A3): .

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Neuroptic Pain, Neuropathy, Research Journal.
Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-A Classification: NLMC Code: WL 103.5
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v1.2

Issue date

July 31, 2021

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English

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As we know that pain is the most common reason for which a patient takes medicine. Pain is not a single entity but may be classified as nociceptive pain, inflammatory pain, and neuropathic pain. Nociceptive pain such pain can be healed or cured by using NSAIDs and other analgesics. Neuropathic pain is caused by the direct lesion on the neuron or damage or dysfunction of peripheral or central neurons. Minor neuropathic can cured automatically because peripheral nervous systems neuron surrounded by Schwann cell which promotes the healing of neurons but CNS neurons don’t have Schwan cell they are covered with oligodendrocytes which don’t have self healing property so pain mediated through CNS are generally chronic. Even the smallest stimulation results in spontaneous intense pain after that it gets transformed into chronic pain syndrome which is difficult to treat.In chronic pain syndrome, plastic changes occur in nociceptive neurons which cant be reversed by pharmacological treatment. In this review, we have discussed the core pathophysiology of neuropathic pain and advances in it to date.

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Neuropathic Pain: Basic to Advanced Neuropathic Pain

Santosh Nagare
Santosh Nagare

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