On the Role of Luminal Flow and Interstrut Distance in Modelling Drug Transport from Half-Embedded Drug-Eluting Stent

On the Role of Luminal Flow and Interstrut Distance in Modelling Drug Transport from Half-Embedded Drug-Eluting Stent

Prashanta Kumar Mandal M.Sc., Ph.D.

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Akash Pradip Mandal

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Visva-Bharati University

On the Role of Luminal Flow and Interstrut Distance in Modelling Drug Transport from Half-Embedded Drug-Eluting Stent

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Abstract

A model for investigating the transport of drug from a half-embedded drug-eluting stent (DES) is developed. Keeping the relevance of the physiological situation in view, the luminal drug transport is considered as an unsteady convection-diffusion process, while the drug transport within the arterial tissue is supposed to commence as a diffusion process. The Marker and Cell (MAC) method has been used to handle numerically the governing equations of motion for the luminal flow and the drug transport through the lumen and the tissue. The effects of quantities of significance such as Reynolds number (Re), Womersley number (α) and interstrut distance on the transport of drug through both the lumen and the tissue are quantitatively investigated. Our simulation predicts that the mean concentration of drug increases with the decreases of Reynolds number and with an increase in the Womersley number.

References

27 Cites in Article

Reference Format

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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How to Cite This Article

Prashanta Kumar Mandal. 2017. \u201cOn the Role of Luminal Flow and Interstrut Distance in Modelling Drug Transport from Half-Embedded Drug-Eluting Stent\u201d. Global Journal of Science Frontier Research - F: Mathematics & Decision GJSFR-F Volume 16 (GJSFR Volume 16 Issue F6): .

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GJSFR Volume 16 Issue F6
Pg. 37- 52

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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GJSFR-F Classification: MSC 2010: 00A05

Submission ReceivedOctober 1, 2016
Peer Review Double Blind
Handling Editor
Accepted October 23, 2016
Published November 7, 2016

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v1.2

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January 19, 2017

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Article Matrices

Total Score: 102

Country: Unknown

Subject: Global Journal of Science Frontier Research - F: Mathematics & Decision

Authors: Akash Pradip Mandal, Prashanta Kumar Mandal (PhD/Dr. count: 0)

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Publish Date: 2017 01, Thu

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