Oncolytic Activity of Bacteria used in Cancerous Disease Gene Therapy

Alexandra Valencakova; Elena Hatalova

Oncolytic Activity of Bacteria used in Cancerous Disease Gene Therapy

Alexandra Valencakova * §

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Elena Hatalova

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§ University of Veterinary Medicine and Pharmacy

Oncolytic Activity of Bacteria used in Cancerous Disease Gene Therapy

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Abstract

Gene therapy is a therapeutic strategy based on using genes as pharmaceuticals. Gene therapy holds promise for treating a wide range of diseases, including cancer, cystic fibrosis, heart disease, diabetes, hemophilia and AIDS. Various types of genetic material are used in gene therapy; double-strained DNA (dsDNA), single strained DNA (ssDNA), plasmid DNA and antisense oligodeoxynucleotides (ASON), adenoviruses, retroviruses, undeveloped/ plasmid DNA and bacteria. The use of bacteria in cancer therapy can be advantageous for various reasons compared to classic chemotherapy or other microorganisms. Bacteria can adhere and invade tumor cells, and they are capable of proliferation and of establishing extracellular colonies. Other than that, their genome length enables them to be recipient to a quantum of exogenous therapeutic genes (for example, enzymes activating precursors and cytokines). The most important thing from the clinical safety view is they can be killed by antibiotics (such as metronidazole) if complications in further treatment arise. For comparison, the capacity of viral vectors is limited and in case of side effects viruses cannot be eliminated by antibiotics.

References

40 Cites in Article

Reference Format

R Jain,L Baxter (1988). Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.
Panos Lehouritis,Caroline Springer,Mark Tangney (2013). Bacterial-directed enzyme prodrug therapy.
Nigel Minton,Margaret Mauchline,Marylin Lemmon,John Brehm,Mary Fox,N Michael,Amato Giaccia,J Brown (1995). Chemotherapeutic tumour targeting using clostridial spores.
R Malmgren,C Flanigan (1955). Localization of the vegetative form of Clostridium tetani in mouse tumors following intravenous spore administration.
K Engelbart,D Gericke (1964). Oncolysis by clostridia. V. Transplanted tumors of the hamster.
R Carey,J Holland,P Sheehe,S Graham (1967). Association of cancer of the breast and acute myelocytic leukemia.
D Gericke,Engelbart (1964). Oncolysis by clostridia. Ii. Experiments on a tumor spectrum with a variety of clostridia in combination with heavy metal.
D Gericke,F Dietzel,W König,I Rüster,L Schumacher (1979). Further progress with oncolysis due to apathogenic clostridia.
F Dietzel,D Gericke (1977). Intensification of the oncolysis by clostridia by means of radio-frequency hyperthermy in experiments on animals--dependence on dosage and on intervals (author'stransl).
L Dang,C Bettegowda,D Huso,K Kinzler,B Vogelstein (2001). Combination bacteriolytic therapy for the treatment of experimental tumors.
Chetan Bettegowda,Long Dang,Ross Abrams,David Huso,Larry Dillehay,Ian Cheong,Nishant Agrawal,Scott Borzillary,J Mccaffery,E Watson,Kuo-Shyan Lin,Fred Bunz,Kwamena Baidoo,Martin Pomper,Kenneth Kinzler,Bert Vogelstein,Shibin Zhou (2003). Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria.
Ian Cheong,Shibin Zhou (2009). Chapter 13 Tumor-Specific Liposomal Drug Release Mediated by Liposomase.
Nicholas Roberts,Linping Zhang,Filip Janku,Amanda Collins,Ren-Yuan Bai,Verena Staedtke,Anthony Rusk,David Tung,Maria Miller,Jeffrey Roix,Kristen Khanna,Ravi Murthy,Robert Benjamin,Thorunn Helgason,Ariel Szvalb,Justin Bird,Sinchita Roy-Chowdhuri,Halle Zhang,Yuan Qiao,Baktiar Karim,Jennifer Mcdaniel,Amanda Elpiner,Alexandra Sahora,Joshua Lachowicz,Brenda Phillips,Avenelle Turner,Mary Klein,Gerald Post,Luis Diaz,Gregory Riggins,Nickolas Papadopoulos,Kenneth Kinzler,Bert Vogelstein,Chetan Bettegowda,David Huso,Mary Varterasian,Saurabh Saha,Shibin Zhou (2014). Intratumoral injection of <i>Clostridium novyi</i> -NT spores induces antitumor responses.
L Dang,C Bettegowda,N Agrawal,I Cheong,D Huso,P Frost,F Loganzo,L Greenberger,J Barkoczy,G Pettit,Smith Ab 3rd,H Gurulingappa,S Khan (2004). Targeting vascular and avascular compartments of tumors with C. novyi-NT and antimicrotubule agents.
L Diaz,Jr,I Cheong,C Foss,X Zhang,B Peters,N Agrawal,C Bettegowda,B Karim,G Liu,K Khan,X Huang,M Kohli,L Dang (2005). Pharmacologic and toxicologic evaluation of C. novyi-NT spores.
J Theys,O Pennington,L Dubois (2006). Repeated cycles of Clostridium-directed enzyme prodrug therapy resultin sustained antitumour effects in vivo.
S Liu,G Ahn,M Kioi (2008). Optimized clostridium-directed enzyme prodrug therapy improves the antitumor activity of the novel DNA cross-linking agent PR-104.
J Theys,P Lambin (2015). Clostridium to treat cancer: dream or reality?.
J Heap,J Theys,M Ehsaan (2014). Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo.
D Bermudes,B Low,J Pawelek (2000). Tumor-targeted Salmonella. Highly selective delivery vectors.
Kenneth Low,Martina Ittensohn,Xiang Luo,Li-Mou Zheng,Ivan King,John Pawelek,David Bermudes (2004). Construction of VNP20009: A Novel, Genetically Stable Antibiotic-Sensitive Strain of Tumor-Targeting Salmonella for Parenteral Administration in Humans.
K Low,Martina Ittensohn,Trung Le,James Platt,Stefano Sodi,Max Amoss,Olivia Ash,Ellen Carmichael,Ashok Chakraborty,Jessica Fischer,Stanley Lin,Xiang Luo,Samuel Miller,Li-Mou Zheng,Ivan King,John Pawelek,David Bermudes* (1999). Lipid A mutant Salmonella with suppressed virulence and TNFα induction retain tumor-targeting in vivo.
J Toso,V Gill,P Hwu,F Marincola,N Restifo,D Schwartzentruber,R Sherry,S Topalian,J Yang,F Stock,L Freezer,K Morton,C Seipp,L Haworth,S Mavroukakis,D White,S Macdonald,J Mao,M Sznol,S Rosenberg (2002). Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma.
L Zheng,X Luo,M Feng,Z Li,T Le,M Ittensohn,M Trailsmith,D Bermudes,S Lin,I King (2000). Tumor amplified protein expression therapy: Salmonella as a tumor-selective protein delivery vector.
J Pawelek,S Sodi,A Chakraborty,J Platt,S Miller,D Holden,M Hensel,K Low (2002). Salmonella pathogenicity island-2 and anticancer activity in mice.
Francesca Avogadri,Chiara Martinoli,Liljana Petrovska,Claudia Chiodoni,Pietro Transidico,Vincenzo Bronte,Renato Longhi,Mario Colombo,Gordon Dougan,Maria Rescigno (2005). Cancer Immunotherapy Based on Killing of <i>Salmonella</i> -Infected Tumor Cells.
K Westphal,S Leschner,J Jablonska,H Loessner,S Weiss (2008). Containment of tumor-colonizing bacteria by host neutrophils.
Y Barak,F Schreiber,S Thorne,C Contag,D Debeer,A Matin (2010). Role of nitric oxide in Salmonella typhimurium-mediated cancer cell killing.
D Morrissey,O' Sullivan,G Tangney,M (2010). Tumour targeting with systemically administered bacteria.
K Bagshawe (1987). Antibody directed enzymes revive anti-cancer prodrugs concept.
K Bagshawe (1990). Antibody-directed enzyme/prodrug therapy (ADEPT).
L Tietze,K Schmuck (2011). Prodrugs for targeted tumor therapies: recent developments in ADEPT, GDEPT and PMT.
A Lukashev,V Lashkevich,O Ivanova,G Koroleva,A Hinkkanen,J Ilonen (2005). Recombination in circulating Human enterovirus B: independent evolution of structural and non-structural genome regions.
R Satchi-Fainaro,H Hailu,J Davies,C Summerford,R Duncan (2003). PDEPT: polymer-directed enzyme prodrug therapy. 2. HPMA copolymer-betalactamase and HPMA copolymer-C-Dox as a model combination.
R Spooner,F Friedlos,K Maycroft,S Stribbling,J Roussel,J Brueggen,B Stolz,T O'reilly,J Wood,A Matter,R Marais,C Springer (2003). A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs.
Sarah Knaggs,Hugh Malkin,Helen Osborn,Nana Williams,Parveen Yaqoob (2005). New prodrugs derived from 6-aminodopamine and 4-aminophenol as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT).
L Tietze,H Schuster,K Schmuck,I Schuberth,F Alves (2008). Duocarmycin-based prodrugs for cancer prodrug monotherapy.
I Niculescu-Duvaz,R Spooner,R Marais,C Springer (1998). Gene-directed enzyme prodrug therapy.
F Moolten (1986). Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.
Laetitia Finzi,Aurore Kraemer,Claude Capron,Severine Noullet,Diane Goere,Christophe Penna,Bernard Nordlinger,Josette Legagneux,Jean-Fançois Emile,Robert Malafosse (2011). Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Alexandra Valencakova, Elena Hatalova. 2016. "Oncolytic Activity of Bacteria used in Cancerous Disease Gene Therapy". Global Journal of Medical Research - F: Diseases GJMR-F Volume 16 (GJMR Volume 16 Issue F3).

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GJMR Volume 16 Issue F3

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-F Classification NLMC Code: QW 167

Submission ReceivedDecember 10, 2015
Peer Review Double Blind
Handling Editor
Accepted January 3, 2016
Published January 15, 2016

Version of record

v1.2

Issue date

July 4, 2016

Language

English

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Article Matrices

Total Score: 146

Country: Slovakia

Subject: Global Journal of Medical Research

Authors: Valencakova, A ,Dziakova, A., Hatalova, E. (PhD/Dr. count: 0)

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