Oxidative Stress in Dogs in Different Stages of Chronic Kidney Disease

Andre B. Galvao

Oxidative Stress in Dogs in Different Stages of Chronic Kidney Disease

Andre B. Galvao *

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Oxidative Stress in Dogs in Different Stages of Chronic Kidney Disease

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Abstract

The objective of this study to quantify oxidative stress in dogs with naturally acquied chronic kidney disease (CKD), considering the four stages of disease progression, using as markers reactive substances to thiobarbituric acid. Five groups of dogs, all aged between four to 18 years old. Were studied the control group was composed of healthy animals (CG, n = 17), CKD stage 1 group (CKD-1, n = 12), CKD stage 2 group (CKD-2, n = 10), CKD stage 3 group (CKD-3, n = 13) and CKD stage 4 group (CKD-4, n = 10). Oxidative stress was measured by antioxidante power, using as markers reactive substances to thiobarbituric acid. Data (means of duplicates) were submitted to analysis of variance (One-way ANOVA) nonparametric (Kruskal-Wallis) (α =0.05). The results were expressed as mean±standard error of the mean. The serumcreatinine values guided the classification of patients as CG, CKD-1, CKD-2, CKD-3 and CKD-4 andwere 1.02±0.02 mg/dL, 1.06±0.05 mg/dL, 1.80±0.03 mg/dL, 3.39±0.21 mg/dL and 6.00±0.28 mg/dL, respectively. The results related to antioxidant power (GC) 0.032±0.002 mmol/μL, (CKD-1) 0.030±0.002 nmol/μL, (CKD-2) 0.028±0.003 nmol/μL, (CKD-3) 0.027±0.003 nmol/μL and (CKD-4) 0.025 ± 0.002 nmol/μL.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Andre B. Galvao. 2018. "Oxidative Stress in Dogs in Different Stages of Chronic Kidney Disease". Global Journal of Medical Research - G: Veterinary Science & Medicine GJMR-G Volume 18 (GJMR Volume 18 Issue G1).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-G Classification NLMC Code: WA 360

Submission ReceivedDecember 14, 2017
Peer Review Double Blind
Handling Editor
Accepted January 5, 2018
Published January 15, 2018

Version of record

v1.2

Issue date

June 6, 2018

Language

Portuguese

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Article Matrices

Total Score: 106

Country: Brazil

Subject: Global Journal of Medical Research - G: Veterinary Science & Medicine

Authors: Andre B. Galvao, Marileda B. Carvalho, Luciane G. Batalho, Juliana C.B. Silva, Marcelo Batalho, Evelin C. Carnio (PhD/Dr. count: 0)

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