Paracetamol May Increase Cardiac Congenital Malformations Risk in Prediabetic Pregnancy Women

Paracetamol May Increase Cardiac Congenital Malformations Risk in Prediabetic Pregnancy Women

Dr. Juan Ariel Jara-Guerrero

Contact

Universidad Complutense de Madrid

Paracetamol May Increase Cardiac Congenital Malformations Risk in Prediabetic Pregnancy Women

Article Fingerprint

ReserarchID

F4JYI

Paracetamol May Increase Cardiac Congenital Malformations Risk in Prediabetic Pregnancy Women Banner

AI TAKEAWAY

Connecting with the Eternal Ground

References

88 Cites in Article

Reference Format

Stefanie Adam,Omar Elfeky,Vyjayanthi Kinhal,Suchismita Dutta,Andrew Lai,Nanthini Jayabalan,Zarin Nuzhat,Carlos Palma,Gregory Rice,Carlos Salomon (2017). Review: Fetal-maternal communication via extracellular vesicles – Implications for complications of pregnancies.
V Allen,B Armson,R Wilson,V Allen,C Blight,A Gagnon,J Johnson,S Langlois,A Summers,P Wyatt,D Farine,B Armson,J Crane,M Delisle,L Keenan-Lindsay,V Morin,C Schneider,J Van Aerde (2007). Society of Obstetricians and Gynecologists of Canada Teratogenicity associated with preexisting and gestational diabetes.
T Andersen,Troelsen Kde,L Larsen,L (2014). Of mice and men: molecular genetics of congenital heart disease.
Lester Baker,Joseph Egler,Steven Klein,Allen Goldman (1981). Meticulous Control of Diabetes During Organogenesis Prevents Congenital Lumbosacral Defects in Rats.
A Bauer,D Kriebel (2013). Prenatal and perinatal analgesic exposure and autism: an ecological link.
M Beck,C Mclellan,Null- Lightle,M Philbert,C Harris (2001). Spatial Glutathione and Cysteine Distribution and Chemical Modulation in the Early Organogenesis-Stage Rat Conceptus in Utero.
Jos Bessems,Nico Vermeulen (2001). Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches.
F Burdan,E Starosławska (2012). Szumiło J Prenatal tolerability of acetaminophen and other over-thecounter non-selective cyclooxygenase inhibitors.
Lu Cai,Wei Li,Guangwu Wang,Luping Guo,Youchun Jiang,Y Kang (2002). Hyperglycemia-Induced Apoptosis in Mouse Myocardium.
Niamh Corrigan,Derek Brazil,Fionnuala Mcauliffe (2009). Fetal cardiac effects of maternal hyperglycemia during pregnancy.
M Da Silva,E Da Rosa,N De Carvalho,F Dobrachinski,J Da Rocha,J Mauriz,J González-Gallego,F Soares (2011). Acute brain damage induced by acetaminophen in mice: effect of diphenyl diselenide on oxidative stress and mitochondrial dysfunction.
Michel De Lorgeril,Patricia Salen,Michèle Accominotti,Monique Cadau,Jean-Paul Steghens,François Boucher,Joël De Leiris (2001). Dietary and Blood Antioxidants in Patients with Chronic Heart Failure. Insights into the Potential Importance of Selenium in Heart Failure.
De Souza,L Berger,H Retnakaran,R Vlachou,P Maguire,J Nathens,A Connelly,P Ray,J (2016). Hepatic fat and abdominal adiposity in early pregnancy together predict impaired glucose homeostasis in mid-pregnancy.
Ulf Eriksson,Elisabeth Dahlström,K Larsson,Claes Hellerström (1982). Increased Incidence of Congenital Malformations in the Offspring of Diabetic Rats and Their Prevention by Maternal Insulin Therapy.
U Eriksson,J Styrud (1985). Congenital Malformations in Diabetic Pregnancy: the Clinical Relevance of Experimental Animal Studies.
Ulf Eriksson,Parri Wentzel (2016). The status of diabetic embryopathy.
H Farquhar,A Stewart,E Mitchell,J Crane,S Eyers,M Weatherall,R Beasley (2010). The role of paracetamol in the pathogenesis of asthma.
E Fine,M Horal,T Chang,G Fortin,M Loeken (1999). Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy..
Fabio Fiordaliso,Annarosa Leri,Daniela Cesselli,Federica Limana,Bijan Safai,Bernardo Nadal-Ginard,Piero Anversa,Jan Kajstura (2001). Hyperglycemia Activates p53 and p53-Regulated Genes Leading to Myocyte Cell Death.
Andrea Frustaci,Jan Kajstura,Cristina Chimenti,Igor Jakoniuk,Annarosa Leri,Attilio Maseri,Bernardo Nadal-Ginard,Piero Anversa (2000). Myocardial Cell Death in Human Diabetes.
K Fuhrmann,H Reiher,K Semmler,E Glöckner (1984). The Effect of Intensified Conventional Insulin Therapy before and during Pregnancy on the Malformation Rate in Offspring of Diabetic Mothers.
Ryuichi Fukuda,Alla Aharonov,Yu Ong,Oliver Stone,Mohamed El-Brolosy,Hans-Martin Maischein,Michael Potente,Eldad Tzahor,Didier Stainier (2019). Metabolic modulation regulates cardiac wall morphogenesis in zebrafish.
E Giavini,M Broccia,M Prati,Domenico Roversi,G (1991). Diet composition modifies embryotoxic effects induced by experimental diabetes in rats.
E Giavini (1993). Diabetes in pregnancy: experimental aspects.
Sanjoy Ghosh,Thomas Pulinilkunnil,Gloria Yuen,Girish Kewalramani,Ding An,Dake Qi,Ashraf Abrahani,Brian Rodrigues (2005). Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion.
Annelene Govindsamy,Strinivasen Naidoo,Marlon Cerf (2018). Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease.
J Gutierrez,Terry Hrubec,M Prater,Bonnie Smith,Larry Freeman,Steven Holladay (2007). Aortic and ventricular dilation and myocardial reduction in gestation day 17 ICR mouse fetuses of diabetic mothers.
J Gutierrez,M Prater,B Smith,L Freeman,M Mallela (2009). Holladay SD Late-gestation ventricular myocardial reduction in fetuses of hyperglycemic CD1 mice is associated with increased apoptosis Birth Defects.
A Hamlyn,A Douglas,O James (1978). The spectrum of paracetamol (acetaminophen) overdose: clinical and epidemiological studies.
J Hoet,Adrienne Gommers,J Hoet (1962). Causes of Congenital Malformations: Rôle of Prediabetes and Hypothyroidism.
Yasushi Honda,Takaomi Kessoku,Yoshio Sumida,Takashi Kobayashi,Takayuki Kato,Yuji Ogawa,Wataru Tomeno,Kento Imajo,Koji Fujita,Masato Yoneda,Koshi Kataoka,Masataka Taguri,Takeharu Yamanaka,Yuya Seko,Saiyu Tanaka,Satoru Saito,Masafumi Ono,Satoshi Oeda,Yuichiro Eguchi,Wataru Aoi,Kenji Sato,Yoshito Itoh,Atsushi Nakajima (2017). Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study.
Rivka Horowitz,Richard Dart,David Jarvie,Cynthia Bearer,Usha Gupta (1997). Placental Transfer of<i>N</i>-Acetylcysteine Following Human Maternal Acetaminophen Toxicity.
Miwa Ishibashi,Shoichi Akazawa,Hiroyuki Sakamaki,Kazunari Matsumoto,Hironori Yamasaki,Yoshihiko Yamaguchi,Shinji Goto,Yoshishige Urata,Takahito Kondo,Shigenobu Nagataki (1997). Oxygen-Induced Embryopathy and the Significance of Glutathione-Dependent Antioxidant System in the Rat Embryo During Early Organogenesis.
Nanthini Jayabalan,Soumyalekshmi Nair,Zarin Nuzhat,Gregory Rice,Felipe Zuñiga,Luis Sobrevia,Andrea Leiva,Carlos Sanhueza,Jaime Gutiérrez,Martha Lappas,Dilys Freeman,Carlos Salomon (2017). Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes.
Marlon Jetten,Stan Gaj,Ainhoa Ruiz-Aracama,Theo De Kok,Joost Van Delft,Arjen Lommen,Eugene Van Someren,Danyel Jennen,Sandra Claessen,Ad Peijnenburg,Rob Stierum,Jos Kleinjans (2012). 'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.
Yoshiharu Kaneo,Kyoko Ogawa,Tetsuro Tanaka,Yumie Fujihara,Sadao Iguchi (1994). A Protective Effect of Glutathione-Dextran Macromolecular Conjugates on Acetaminophen-Induced Hepatotoxicity Dependent on Molecular Size..
Barbora Konečná,Ľubomíra Tóthová,Gabriela Repiská (2019). Exosomes-Associated DNA—New Marker in Pregnancy Complications?.
A Larson,J Polson,R Fontana,T Davern,E Lalani,L Hynan,J Reisch,F Schiødt,G Ostapowicz,A Shakil,W Lee (2005). Acute Liver Failure Study Group Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.
Taylor Lawson,Devon Scott-Drechsel,Venkat Chivukula,Sandra Rugonyi,Kent Thornburg,Monica Hinds (2018). Hyperglycemia Alters the Structure and Hemodynamics of the Developing Embryonic Heart.
A Lee,D Reis,U Eriksson (1999). Hyperglycemia-induced embryonic dysmorphogenesis correlates with genomic DNA mutation frequency in vitro and in vivo..
Lukas Lisowski,Paul Verheijen,Joshua Copel,Charles Kleinman,Sander Wassink,Gerard Visser,Erik-Jan Meijboom (2010). Congenital Heart Disease in Pregnancies Complicated by Maternal Diabetes Mellitus.
Clemente López-Quijada,Luis Carrion (1974). Maternal disorders of carbohydrate metabolism in cases of cardiac embryopathy.
E Menegola,M Broccia,M Prati,R Ricolfi,E Giavini (1996). Glutathione status in diabetes-induced embryopathies.
James Mills,Robert Knopp,Joe Simpson,Lois Jovanovic-Peterson,Boyd Metzger,Lewis Holmes,Jerome Aarons,Zane Brown,George Reed,Frederick Bieber,Margot Van Allen,Ian Holzman,Carole Ober,Charles Peterson,Marcia Withiam,Anne Duckles,Eberhard Mueller-Heubach,B Polk (1988). Lack of Relation of Increased Malformation Rates in Infants of Diabetic Mothers to Glycemic Control during Organogenesis.
James Mills,James Troendle,Mary Conley,Tonia Carter,Charlotte Druschel (2010). Maternal obesity and congenital heart defects: a population-based study.
J Mitchell,D Jollow,W Potter,J Gillette,B Brodie (1973). ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE.
Murray Mitchell,Hassendrini Peiris,Miharu Kobayashi,Yong Koh,Gregory Duncombe,Sebastian Illanes,Gregory Rice,Carlos Salomon (2015). Placental exosomes in normal and complicated pregnancy.
H Moazzen,X Lu,N Ma,T Velenosi,B Urquhart,L Wisse,A Groot,Q Feng (2014). N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes.
Soumyalekshmi Nair,Nanthini Jayabalan,Dominic Guanzon,Carlos Palma,Katherin Scholz-Romero,Omar Elfeky,Felipe Zuñiga,Valeska Ormazabal,Emilio Diaz,Gregory Rice,Gregory Duncombe,Thomas Jansson,Harold Mcintyre,Martha Lappas,Carlos Salomon (2018). Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity.
V Navarrete,C Rojas,C Alger,H Paniagua (1970). SUBSEQUENT DIABETES IN MOTHERS DELIVERED OF A MALFORMED INFANT.
J Neto,R Oliveira-Filho,M Simões,J Soares,Jr,L Kulay (2004). Long-term acetaminophen (paracetamol) treatment causes liver and kidney ultra-structural changes during rat pregnancy.
G Nielsen,B Nørgard,E Puho,K Rothman,H Sørensen,A Czeizel (2005). Risk of specific congenital abnormalities in offspring of women with diabetes.
G Passarella,G Trifirò,M Gasparetto,G Moreolo,O Milanesi (2013). Disorders in Glucidic Metabolism and Congenital Heart Diseases: Detection and Prevention.
G Paolisso,A D'amore,D Giugliano,A Ceriello,M Varricchio,F D'onofrio (1993). Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients.
Emese Pinter,E Reece,Csaba Leranth,Mrinal Sanyal,John Hobbins,Maurice Mahoney,Frederick Naftolin (1986). Yolk sac failure in embryopathy due to hyperglycemia: Ultrastructural analysis of yolk sac differentiation associated with embryopathy in rat conceptuses under hyperglycemic conditions.
E Pinter,J Haigh,A Nagy,J Madri (2001). Hyperglycemiainduced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation.
E Reece,Ying-King Wu (1997). Prevention of diabetic embryopathy in offspring of diabetic rats with use of a cocktail of deficient substrates and an antioxidant.
D Reed,M Fariss (1984). Glutathione depletion and susceptibility..
Ashleigh A. Richards,Vidu Garg (2010). Genetics of Congenital Heart Disease.
G Rice,K Scholz-Romero,E Sweeney,H Peiris,M Kobayashi,G Duncombe,M Mitchell,C Salomon (2015). The Effect of Glucose on the Release and Bioactivity of Exosomes From First Trimester Trophoblast Cells.
Pauline Roest,Liesbeth Van Iperen,Shirley Vis,Lambertus Wisse,Rob Poelmann,Regine Steegers‐theunissen,Daniel Molin,Ulf Eriksson,Adriana Gittenberger‐de Groot (2007). Exposure of neural crest cells to elevated glucose leads to congenital heart defects, an effect that can be prevented by N‐acetylcysteine.
Melissa Roman (2011). Preconception Care for Women With Preexisting Type 2 Diabetes.
T Roušar,E Nýdlová,P Česla,P Staňková,O Kučera,P Pařík,Z Červinková (2012). Purified Acetaminophen-Glutathione Conjugate Is Able To Induce Oxidative Stress in Rat Liver Mitochondria.
Edmond Ryan (1998). PREGNANCY IN DIABETES.
H Sakamaki,S Akazawa,M Ishibashi,K Izumino,H Takino,H Yamasaki,Y Yamaguchi,S Goto,Y Urata,T Kondo,S Nagataki (1999). Significance of glutathione-dependent antioxidant system in diabetes-induced embryonic malformations..
C Salomon,G Rice (2017). Role of Exosomes in Placental Homeostasis and Pregnancy Disorders.
Young Seo,Jun Lee,Eun Lee,Hye Lee,Hae Kim,Young-Hoon Kim (2004). Role of glutathione in the adaptive tolerance to H2O2.
Scott-Drechsel De,S Rugonyi,D Marks,K Thornburg,M Hinds (2013). Hyperglycemia slows embryonic growth and suppresses cell cycle via cyclin D1 and p21.
Ruijing Shi,Lianbi Zhao,Wenbin Cai,Mengying Wei,Xueying Zhou,Guodong Yang,Lijun Yuan (2017). Maternal exosomes in diabetes contribute to the cardiac development deficiency.
C Simán,U Eriksson (1997). Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats.
Martin Simán (1997). Congenital Malformations in Experimental Diabetic Pregnancy: Aetiology and Antioxidative Treatment.
I Sudano,A Flammer,D Periat,F Enseleit,M Hermman,M Wolfrum,A Hirt,P Kaiser,D Hurlimman,M Neidhart,S Gay,J Holzmeister,J Nussberger,P Mocharla,U Landmesser,S Haile,R Corti,P Vanhoutte,T Luscher,G Noil (2010). Ruschitzka F Acetaminophen Increases Blood Pressure in Ambulatory Patients With Coronary Artery.
Ashish Sule,Dessmon Tai,Choong-Charn Tze,Balakrishnan Deepa,Melvin Leow (2006). Potentially Fatal Paracetamol Overdose and Successful Treatment with 3 Days of Intravenous N-acetylcysteine Regime – A Case Report.
Johan Styrud,Lennart Thunberg,Olof Nybacka,Ulf Eriksson (1995). Correlations between Maternal Metabolism and Deranged Development in the Offspring of Normal and Diabetic Rats.
K Todorova,V Mazneĭkova,S Ivanov,M Genova (2005). The frequency of mild and severe fetal malformations in diabetic women with high values of glycosilated hemoglobin in early pregnancy.
A Torchinsky,V Toder,H Carp,H Orenstein,A Fein (1997). In vivo evidence for the existence of a threshold for hyperglycemia-induced major fetal malformations: relevance to the etiology of diabetic teratogenesis.
R Trocino,S Akazawa,M Ishibashi,K Matsumoto,H Matsuo,H Yamamoto,S Goto,Y Urata,T Kondo,S Nagataki (1995). Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture.
R Ucheya,J Igweh (2006). Histological changes in kidney structure following a long-term administration of paracetamol (acetaminophen) in pregnant Sprague Dawley rats Niger.
Nosratola Vaziri,Xiu Wang,Fariba Oveisi,Behdad Rad (2000). Induction of Oxidative Stress by Glutathione Depletion Causes Severe Hypertension in Normal Rats.
P Wentzel,U Eriksson (1996). Insulin treatment fails to abolish the teratogenic potential of serum from diabetic rats.
P Wentzel,L Thunberg,U Eriksson (1997). Teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and Nacetylcysteine in rat embryo culture.
Parri Wentzel,Mattias Gäreskog,Ulf Eriksson (2008). Decreased Cardiac Glutathione Peroxidase Levels and Enhanced Mandibular Apoptosis in Malformed Embryos of Diabetic Rats.
D Whitcomb,G Block (1994). Association of acetaminophen hepatotoxicity with fasting and ethanol use.
P Wu (1996). Infant of diabetic mother: a continuing challenge for perinatal-neonatal medicine Zhonghua Min Guo Xiao Er.
X Yang,L Borg,U Eriksson (1995). Altered mitochondrial morphology of rat embryos in diabetic pregnancy.
Sheller Zabihi,Mary Loeken (2010). Understanding diabetic teratogenesis: Where are we now and where are we going?.
Jianxiang Zhong,Shengbing Wang,Wei-Bin Shen,Sunjay Kaushal,Peixin Yang (2018). The current status and future of cardiac stem/progenitor cell therapy for congenital heart defects from diabetic pregnancy.
Xiang Zhou,Xiang Lu (2013). The role of oxidative stress in high glucose-induced apoptosis in neonatal rat cardiomyocytes.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr. Juan Ariel Jara-Guerrero. 2020. \u201cParacetamol May Increase Cardiac Congenital Malformations Risk in Prediabetic Pregnancy Women\u201d. Global Journal of Medical Research - F: Diseases GJMR-F Volume 20 (GJMR Volume 20 Issue F7): .

More Citation Formats

Select Citation Style:

Download Citation

Download Article

GJMR Volume 20 Issue F7
Pg. 39- 47

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Not Found

Classification

GJMR-F Classification: NLMC Code: WG 220

Submission ReceivedDecember 11, 2019
Peer Review Double Blind
Handling Editor
Accepted December 31, 2019
Published January 15, 2020

Version of record

v1.2

Issue date

July 24, 2020

Language

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Views: 2299

Total Downloads: 1165

2026 Trends

Published Article

Abstract not found

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]