Phytochemical and Pharmacological Evaluation of Fruits of Sonneratia apetala

Phytochemical and Pharmacological Evaluation of Fruits of Sonneratia apetala

Anha Afrin Shefa

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Farzana Shabnam Baishakhi

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Sharmin Islam

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Samir Kumar Sadhu

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Khulna University

Phytochemical and Pharmacological Evaluation of Fruits of Sonneratia apetala

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Abstract

Buch.-Ham is a mangrove tree from the family, Lythraceae. The aim of the study is to evaluate analgesic, antidirrhoeal, anthelmintic, cytotoxic activity of the fruits of S. apetala. The extract showed dose dependent analgesic activity using acetic acid induced writhing inhibition of the Swiss albino mice. The extract produced 46% and 69% writhing inhibition at the doses of 250 mg/kg and 500 mg/kg body weight respectively while the standard drug (Diclofenac Sodium) produced 82% writhing inhibition at a dose of 25 mg/kg body weight. In vivo antidiarrheal activity was substantiated by significant prolongation of latent period and decrease in total number of stools at four dose level as compared to standard loperamide. In anthelmintic test the extract showed significant and dose dependent decrease in paralysis time and death time of Haemonchus contortus, where albendazole was used as standard.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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How to Cite This Article

Anha Afrin Shefa. 2014. \u201cPhytochemical and Pharmacological Evaluation of Fruits of Sonneratia apetala\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B3): .

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GJMR Volume 14 Issue B3
Pg. 1- 6

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

analgesic activity anthelmintic test antidiarrheal activity brine shrimp lethality bioassay ham sonneratia apetala-Buch

Submission ReceivedDecember 7, 2013
Peer Review Double Blind
Handling Editor
Accepted January 5, 2014
Published January 15, 2014

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v1.2

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June 13, 2014

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Article Matrices

Total Score: 104

Country: Bangladesh

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Anha Afrin Shefa, Farzana Shabnam Baishakhi, Sharmin Islam, Samir Kumar Sadhu (PhD/Dr. count: 0)

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Total Downloads: 2257

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