Phytochemical and Pharmacological Evaluation of Fruits of Sonneratia apetala

§ Khulna University, Khulna, Bangladesh.

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Phytochemical and Pharmacological Evaluation of Fruits of Sonneratia apetala

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Abstract

Buch.-Ham is a mangrove tree from the family, Lythraceae. The aim of the study is to evaluate analgesic, antidirrhoeal, anthelmintic, cytotoxic activity of the fruits of S. apetala. The extract showed dose dependent analgesic activity using acetic acid induced writhing inhibition of the Swiss albino mice. The extract produced 46% and 69% writhing inhibition at the doses of 250 mg/kg and 500 mg/kg body weight respectively while the standard drug (Diclofenac Sodium) produced 82% writhing inhibition at a dose of 25 mg/kg body weight. In vivo antidiarrheal activity was substantiated by significant prolongation of latent period and decrease in total number of stools at four dose level as compared to standard loperamide. In anthelmintic test the extract showed significant and dose dependent decrease in paralysis time and death time of Haemonchus contortus, where albendazole was used as standard.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Anha Afrin Shefa, Farzana Shabnam Baishakhi, sharmin09ku, sadhu1969. 2014. "Phytochemical and Pharmacological Evaluation of Fruits of Sonneratia apetala". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B3).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
Classification
GJMR-B Classification NLMC Code: QV 4
QV 17
Version of record

v1.2

Issue date
June 13, 2014

Language
English
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Phytochemical and Pharmacological Evaluation of Fruits of Sonneratia apetala

Anha Shefa
Anha Shefa Khulna University, Khulna, Bangladesh.
Farzana Baishakhi
Farzana Baishakhi <p>Khulna University, Khulna, Bangladesh.</p>
<p>Khulna University, Khulna, Bangladesh.</p>
<p>Khulna University, Khulna, Bangladesh.</p>